composite lymphoma

composite lymphoma

A rare lymphoma composed of 2 or more malignant cell lines in the same lymph node. See Lymphoma.
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The other disorders which fall into this miscellaneous category are composite lymphoma, "true" histiocytic lymphoma, extramedullary plasmacytoma, and unclassifiable - or U-cell lymphomas.
The term composite lymphoma was first proposed by Custer to denote "the occurrence of more than one histological pattern of lymphoma in a single patient.
In summary, we present an unusual variant of composite lymphoma composed of nodular sclerosing HD and follicular small cleaved cell lymphoma in a single lymph node.
Composite lymphomas constitute the presence of 2 different types of NHL or a rare association of NHL and HD in a single organ or tissue.
The most plausible explanation for these posttherapy composite lymphomas is the prolonged immunodeficiency associated with the primary lymphoma and/or therapy-induced immune suppression.
Composite lymphomas, with HD variants other than NLPHD and NHL, are rare.
In composite lymphomas of HD and NHL, the least described variant of NHL is follicular small cleaved cell lymphoma.
Nodular Sclerosing Hodgkin Disease (HD) and Follicular Small Cleaved Cell (NHL) Composite Lymphomas
Composite lymphomas that consist of 2 different types of T-cell lymphomas are rare.
In cases with RS-like cells expressing CD30 and CD15, the differential diagnosis includes not only classical Hodgkin lymphomas and non-Hodgkin lymphomas, but also composite lymphomas, especially when RS-like cells are numerous.

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