Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma
. N Engl J Med.
In 4 cases, composite lymphoma was verified by biopsy of the lymph node, and in one case, by bone marrow biopsy.
Nevertheless, a careful evaluation of the immunohistochemical picture of the composite lymphoma uncovered the aberrant expression of CD79a by T cells of PTCL-NOS.
The other disorders which fall into this miscellaneous category are composite lymphoma
, "true" histiocytic lymphoma, extramedullary plasmacytoma, and unclassifiable - or U-cell lymphomas.
(2) In 1977, Kim et al (3) refined the definition of composite lymphoma (CL), limiting it to the presence of 2 distinct and well-defined varieties of lymphoma at a single anatomic site.
Composite lymphoma: a clinicopathologic analysis of nine patients with Hodgkin's disease and B-cell non-Hodgkin's lymphoma.
Kluin, "Activation of the cmyc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma
," New England Journal of Medicine, vol.
The term composite lymphoma was first proposed by Custer to denote "the occurrence of more than one histological pattern of lymphoma in a single patient." The working formulation of non-Hodgkin lymphoma (NHL) defined composite lymphoma as "two distinctly demarcated types of non-Hodgkin's lymphoma or its rare association with Hodgkin's lymphoma within a single organ or tissue." The incidence of these tumors is low, varying from 1% to 4.7%.
In summary, we present an unusual variant of composite lymphoma composed of nodular sclerosing HD and follicular small cleaved cell lymphoma in a single lymph node.
Furthermore, in some cases of composite lymphomas (CHL and FLs) the H/RS cells of the CHL carried the same IgH-bcl2 translocation as the associated FL, further suggesting a common cell of origin [25-27].
Hansmann, "Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical hodgkin's disease and either follicular lymphoma or BCLL," Molecular Medicine, vol.
In cases with RS-like cells expressing CD30 and CD15, the differential diagnosis includes not only classical Hodgkin lymphomas and non-Hodgkin lymphomas, but also composite lymphomas
, especially when RS-like cells are numerous.