The trend of component therapy
is increasing but still majority of the collected blood is transfused as whole blood.
After ensuring this primary objective, subsequent inspections should focus on improving the technical standards, practices, donor management, voluntary blood donations, quality of consumables, automation, rational use of blood, component therapy
, hemovigilance, data management, etc.
The two Foundations provide voluntary blood transfusion services to needy patients suffering from chronic blood disorders requiring blood or blood component therapy
Most of the salient debate in the literature centers on the benefits/risk ratio of blood component therapy
. Besieged with repeated studies on restrictive vs.
Despite having multiple guidelines on indications of blood component therapy
in individual derangements, there is no clear-cut evidence regarding benefit from such transfusions and in practice, transfusions also depend on the availability of blood and blood components.
In developed transfusion centers where component therapy
is the rule, it has been proposed that coagulopathic trauma patients be primarily resuscitated with FFP in a ratio of 1:1:1 to red blood cells and platelets, virtually receiving "reconstituted whole blood." Thus transfusion of fresh whole blood is justified in such circumstances.
The Cell Manipulation Core Facility (CMCF) at Dana-Farber Cancer Institute (DFCI) is a manufacturing facility that produces safe and effective novel cellular component therapy
that meets all regulatory guidelines for clinical use and also facilitates research to be translated from the bench to the bedside.
Patients who were admitted twice during the study period, who received massive transfusion (more than 10 units of blood in a 24-hour period, according to American Society of Anaesthesiologists' Practice Guidelines for Blood Component Therapy
) and those who were admitted in surgical intensive care unit (ICU) were excluded from the study.
His bicytopenia was refractory to component therapy
, and bone marrow smear demonstrated hypercellularity with multiple foci of histiocytes engulfing blood cell components, including erythrocytes, leukocytes and platelets (Fig.
Blood component therapy
has many advantages like more efficient utilization of each unit of blood by taking the advantage of differential storage properties of various elements, reduces exposure of patients to unnecessary cellular elements and plasma proteins, minimizes bacterial contamination and eliminates risk of various non-immunogenic reactions like circulatory overload (Turnwald and Pichler, 1985).
Anesthesiologists from North America contribute outlines of assessment, intraoperative and postoperative issues, positioning, monitoring, equipment and procedures, fluid management and blood component therapy
, neuraxial and regional anesthesia, pharmacology, anesthesia and comorbid diseases, and pediatric and subspecialty issues, along with color atlases of regional anesthesia, transesophageal echocardiography, and procedures.