complex locus

com·plex lo·cus

a set of closely linked genetic loci with a common function, as in the major histocompatibility complex locus.
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PHP-1b results from changes in methylation that occur at the GNAS complex locus (GNAS) (2).
The GNAS complex locus encodes the alpha-subunit of the stimulatory G protein (Gs[alpha]), a ubiquitous signaling protein mediating the actions of many hormones, and gives rise to other gene products, most of which exhibit exclusively monoallelic expression.
Meanwhile, uneven development is also dynamic--it is not only reflected in China's economic takeoff but also stimulates contemporary Chinese writers, filmmakers, and intellectuals to think and produce, and shapes "a highly complex locus where the unevenness stages its historical performances in postsocialist China" (31).
In addition, this experimental setup was designed to assess the efficiency of excision of the marked (lox-flanked) gene from complex locus generated by cobombardment of two separate plasmids, and fate of the cotransformed unmarked gene after Cre/++ lox recombination in the locus.
As a proof of principle, the authors correctly detected trisomy 21 by assessing the methylation density of chromosome 21 and correctly deduced the imprinting status of 4 selected loci: H19 [2] [H19, imprinted maternally expressed transcript (non-protein coding)], KCNQ1OT1 [KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)], MEST (mesoderm specific transcript), and GNAS (GNAS complex locus).
Genetic and physical localization of the soybean Rpg-1b disease resistance gene reveals a complex locus containing several tightly linked families of NBS-LRR genes.
Four loci fulfilled the criteria: H19 [5] [HI9, imprinted maternally expressed transcript (non-protein coding)], KCNQIOTl [KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)], MEST (mesoderm specific transcript), and GNAS (GNAS complex locus).
Genetic and physical mapping of the soybean Rpgl-b disease resistance gene reveals a complex locus containing several tightly linked families of NBS/LRR genes.
The first complex locus involved an RGA probe that detected multiple RFLPs, some of which were linked.
A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyl-transferase isoenzymes with identical carboxyl termini.
They postulated that the [Pl.sub.6] gene is a complex locus, which includes several linked resistance genes.
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