Complicating the situation is that most complex diseases
have a large number of clinical traits such as various symptoms, body metrics and family history, and that genome-wide gene expression profiling can identify tens of thousands of molecular traits associated with the disease," said Xing.
However, relatively few variants have been confirmed for complex diseases
such as cancer, heart disease, and diabetes in which both susceptibility genes and environmental contributors are required for the disease to develop (Botstein and Risch 2003; Hirschhorn et al.
can be best addressed not by studying one specific disease, argues Wang, but by finding mechanistic commonalities underlying the pathogenesis of several diseases.
The improved resolution will help researchers interpret current genome studies aimed at finding common and rarer genetic variants associated with complex diseases
Researchers have long known that complex diseases
such as cancer and heart disease have genetic components that heavily affect their onset, progression, and response to treatment.
IBM (NYSE: IBM), the University of Utah Health Sciences Center and LineaGen Research Corporation has announced a broad collaboration to combine their respective strengths to create an unparalleled clinical genomics infrastructure designed to accelerate the molecular understanding of complex diseases
and ultimately to accelerate the development of novel molecular diagnostics and targeted treatments.
Biotechnology is being applied to a range of market opportunities, from the creation of insect-resistant and herbicide-tolerant crops to the development of new pharmaceuticals that target complex diseases
Reading Human Trials also makes a person with MS feel like a part of the international conversation that is medical research--the conversation that's ongoing, and necessary, for any successful treatment of complex diseases
Washington, Aug 18 (ANI): Earlier humans with genes that were prone to type-1 diabetes and rheumatoid arthritis may have provided them with previously unknown benefits, as a result of which, over the years, the modern man has become more prone to some complex diseases
, says a new study.
Leveraging MDS Proteomics' proprietary proteomics systems and Abgenix' human antibody technologies, the companies have identified up to 150 targets for generation of human therapeutic antibody candidates intended for further development and eventual treatment for a broad range of complex diseases
MS is one of the most complex diseases
I know of," said Dr.
Recent technological advances and a growing appreciation that environmental factors contribute to most complex diseases
provide unprecedented opportunities for developing new research paradigms that bring together interdisciplinary teams of Scientists to move basic environmental health sciences research into clinical and public health practice.