4) Hearing loss -- 19/159 (11) FA = Fanconi anaemia; FANCA = FA, complementation group
2004) Identification of a new complementation group
of the peroxisome biogenesis disorders and PEX14 as the mutated gene.
47 * Abbreviations: FANCC, Fanconi anemia complementation group
C; UBC13, ubiquitin-conjugating enzyme 13.
FA can be divided into 12 complementation groups
(A, B, C, D1, D2, E, F, G, I, J, L and M) defined by cell fusion studies and 11 of the 12 responsible FA genes have been identified [11-13].
6-8 It is reported that xeroderma pigmentosum (XP) complementation groups
in human, XPA to XPG, represent the ratelimiting proteins in the NER pathway.
6 Several XP complementation groups
, XPA to XPG, have been identified, which represent the rate-limiting proteins in the NER mechanism.
Fanconi anemia complementation group
A cells are hypersensitive to chromium(VI)-induced toxicity.
There is genetic heterogeneity identified by somatic cell fusion studies or complementation groups
Genetic Analysis of Indefinite Division in Human Cells: Identification of Four Complementation Groups
," Proceedings of the National Academy of Sciences 85:6042-6046, 1988.
Myles and Sancar's comprehensive 1989 review on DNA Repair pre-dates the recent breakthroughs in cloning the human genes for Fanconi's anemia and several of the xeroderma pigmentosum complementation groups
(reviewed by Barnes, Nature 359: 12-13, 1992).