complementation group


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complementation group

a collection of MUTANT ALLELES that fails to complement and restore the WILD TYPE when tested in all pair-wise combinations (see CIS-TRANS TEST). The complementation group is initially used to define the basic genetic unit of function or CISTRON (now synonymous with GENE).
References in periodicals archive ?
4) Hearing loss -- 19/159 (11) FA = Fanconi anaemia; FANCA = FA, complementation group A.
2004) Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene.
47 * Abbreviations: FANCC, Fanconi anemia complementation group C; UBC13, ubiquitin-conjugating enzyme 13.
FA can be divided into 12 complementation groups (A, B, C, D1, D2, E, F, G, I, J, L and M) defined by cell fusion studies and 11 of the 12 responsible FA genes have been identified [11-13].
6-8 It is reported that xeroderma pigmentosum (XP) complementation groups in human, XPA to XPG, represent the ratelimiting proteins in the NER pathway.
6 Several XP complementation groups, XPA to XPG, have been identified, which represent the rate-limiting proteins in the NER mechanism.
Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity.
There is genetic heterogeneity identified by somatic cell fusion studies or complementation groups.
Genetic Analysis of Indefinite Division in Human Cells: Identification of Four Complementation Groups," Proceedings of the National Academy of Sciences 85:6042-6046, 1988.
Myles and Sancar's comprehensive 1989 review on DNA Repair pre-dates the recent breakthroughs in cloning the human genes for Fanconi's anemia and several of the xeroderma pigmentosum complementation groups (reviewed by Barnes, Nature 359: 12-13, 1992).