However, factor H, factor I, and MCP can mediate the conversion of C3b into the inactive form C3bi, to block the complement reaction
activated by the alternative pathway and to prevent the body from being attacked by the complement system.
Accordingly, for classical complement reaction
SRBCs were sensitised with hemolysin (anti-sheep red blood cell stroma from rabbit, Sigma, Taufkirchen, Germany) diluted 1:75 in Veronal buffered saline (VBS) buffer (containing 3.12 mM Diethylbarbituric acid; 1.82 mM Diethylbarbituric acid sodium salt; 145.45 mM NaCl; 1 mM MgCl2; 0.15 mM CaCl2; pH 7.45; conductivity 13.5 mS).
In earlier research, the authors showed that the introduction of the harmless protein shell that encases the astrovirus, which causes pediatric diarrhea, shuts down two of the three methods used by the complement system to destroy damaged cells, but doesn't interfere with the part of complement reaction
that can offer protection from invading pathogens.
This can be used to demonstrate the stoichiometric nature of the complement reaction
"The complement reaction
is one of the major causes of death of the battlefield.