competitive inhibition


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Related to competitive inhibition: Uncompetitive inhibition

inhibition

 [in″hĭ-bish´un]
1. arrest or restraint of a process.
2. in psychoanalysis, the conscious or unconscious restraining of an impulse or desire. adj., adj inhib´itory.
competitive inhibition inhibition of enzyme activity by an inhibitor (a substrate analogue) that competes with the substrate for binding sites on the enzymes.
contact inhibition inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
noncompetitive inhibition inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.

com·pet·i·tive in·hi·bi·tion

blocking of the action of an enzyme by a compound that binds to the free enzyme, preventing the substrate from binding and thus preventing the enzyme from acting on that substrate. The competitive inhibitor is often a substrate analogue and binds at the active site; however, this is not an absolute requirement for competitive inhibition. Saturating concentrations of substrate can remove the inhibition. Compare: isostery.

com·pet·i·tive in·hi·bi·tion

(kŏm-pet'i-tiv in'hi-bish'ŭn)
Blocking of the action of an enzyme by a compound that binds to the free enzyme, preventing the substrate from binding and thus preventing the enzyme from acting on that substrate.
Synonym(s): selective inhibition.

competitive inhibition

a form of enzyme control in which an inhibitor molecule very similar in structure to the normal SUBSTRATE of an enzyme becomes reversibly bound to the ACTIVE SITE, thus reducing the quantity of enzyme available. However, if excess substrate is present the inhibitor can be forced out by the substrate molecule which takes its place and the reaction proceeds. Compare NONCOMPETITIVE INHIBITION.

inhibition

arrest or restraint of a process.

competitive inhibition
inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.
contact inhibition
inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
end-product inhibition
see feedback inhibition (below).
feedback inhibition
a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.
neurological inhibition
the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.
noncompetitive inhibition
inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.
References in periodicals archive ?
Serotonin and dopamine are subject to competitive inhibition at the transporter.
The overall effect of 2-cp and 4-cp on cell growth and phenol degradation should be determined by an overall evaluation of competitive inhibition and toxicity.
In evaluating the results of these studies, it appeared that most of the decrease in P sorption due to OM addition can be accounted for by considering the amount of P mineralised from the added OM, and not through competitive inhibition of P sorption by DOC compounds.
In addition, the presence of hydroxyl group at C-2 position of triterpenic acid in MA compared with OA could magnify its competitive inhibition on human CYP3A4 activity.
To avoid competitive inhibition two-stage or sequencing reactor systems have been proposed to decouple cell growth and transformation of the non-growth substrate.
The development of antibody to HAV, as measured by a solid-phase competitive inhibition blocking assay or a virus neutralization assay, coincides with a marked diminution in the quantity of viremia and fecal shedding of virus [8, 11].
Imetelstat is a short chain oligonucleotide that binds with high affinity and specificity to the catalytic site of telomerase, resulting in competitive inhibition of enzyme activity.
The Lineweaver-Burke linear transformation of the enzyme velocities versus substrate concentration showed that the ethanolic extract of crude Danshen, Danshen pill and quinidine all show competitive inhibition (Fig.
Our previous studies have demonstrated that Danshen aqueous extract affected the metabolism of cytochrome P450 (CYP) 1A2 substrates through competitive inhibition and altered their clearance in humans and rats (Wang and Yeung 2010).

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