competitive displacement


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competitive displacement

the tendency of one drug to displace another at nonspecific protein-binding sites (e.g., plasma albumin) when both drugs are taken at the same time. Only free drug is able to bind to its specific target proteins. An example is phenylbutazone, which has a greater affinity for binding sites on plasma proteins than warfarin. As a result, if both drugs are taken at the same time, fewer binding sites are available for warfarin, thereby increasing its free concentration in the plasma and increasing its anticoagulant action in the liver to potentially undesirable levels.
References in periodicals archive ?
These results suggest that covalent conjugation of whey protein with gellan is a more effective approach than electrostatic conjugation in strengthening interfacial protein layers and enhancing their resistance against surfactant-induced competitive displacement from the interface.
5 for the competitive displacement of COP from SC4A by 1-butyl-3-methylimidazolium bromide (C4MIm+Br-).
An experimental investigation of the competitive displacement of a native gecko by an invading gecko: no role of parasites.
On the other hand, two observations suggest that competitive displacement by Black-legged Kittiwakes may shape nesting habitat use by Red-legged Kittiwakes: (1) characteristics of nest sites used by Red-legged Kittiwakes overlap to a greater degree with those of Black-legged Kittiwakes than with any other cliff-nesting species on St.
Legacy solutions from Cisco, Avaya, Shoretel, Mitel, Nortel, NEC, Panasonic, Fujitsu and Siemens are eligible and additional competitive displacement offers may be available.
Dominoes represent the largest of many competitive displacement opportunities, and we believe they demonstrate that PTC is gaining share and becoming recognized as the industry leader for both our technology and product development process expertise.
Huston's (1979, 1994) "dynamic equilibrium model" offers just such a general look at the interplay between the rate of competitive displacement and mortality due to physical disturbance, stress, or predation.
i-1]) are relatively constant, indicating a tendency for the differences between body masses to be equal on a logarithmic scale, perhaps because of competitive displacement (Pleasants 1994).
The debate over which test statistics are suitable for detecting competitive displacement has been characterized by a lack of statistical rigor.
In addition to competitive displacement wins in the market, PTC continues to be on the forefront of innovation with our social product development initiative and partnership with Microsoft, our growing product analytics platform, and our Arbortext product information delivery solutions.
One of these was an initial deployment of a CLM solution while the other was a competitive displacement.
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