competitive displacement


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competitive displacement

the tendency of one drug to displace another at nonspecific protein-binding sites (e.g., plasma albumin) when both drugs are taken at the same time. Only free drug is able to bind to its specific target proteins. An example is phenylbutazone, which has a greater affinity for binding sites on plasma proteins than warfarin. As a result, if both drugs are taken at the same time, fewer binding sites are available for warfarin, thereby increasing its free concentration in the plasma and increasing its anticoagulant action in the liver to potentially undesirable levels.
References in periodicals archive ?
These results suggest that covalent conjugation of whey protein with gellan is a more effective approach than electrostatic conjugation in strengthening interfacial protein layers and enhancing their resistance against surfactant-induced competitive displacement from the interface.
McAfee has also put competitive displacement programs in place to spur growth in sales to mid-market companies.
These provide a migration path for users of legacy Reuters products as well as competitive displacement opportunities at regional customers who focus on activity in their home market.
LAS VEGAS -- Company Announces Competitive Displacement Program, Enhancements to PartnerONE and Other Programs to Help Partners Grow
Competitive displacement programs, improved dealer training, enhanced IT systems and improved dealer incentive programs separated winners from the not so lucky.
The new order was awarded to Intervoice as a competitive displacement for an existing system within a separate division of the firm new to Intervoice technology.
The growth potential for the new company derives from its greatly enhanced cross-selling opportunities and its competitive displacement capabilities.
The largest transaction in the quarter was a new customer and a competitive displacement into the U.
In the past year, adoption by the Fortune 50 has also nearly doubled to more than 25% of the largest companies in the US, competitive displacements have accelerated, channel and OEM partners are signing on rapidly, and a number of product releases have established Centrify as the most innovative vendor in the marketplace.
25, 2011/PRNewswire/ -- IBM (NYSE: IBM) today announced continued momentum in the worldwide server market, with market share gains reported by a major analyst firm and increased competitive displacements in the second quarter of 2011.
With more than 100 enterprise installations and 12 competitive displacements, 2009 was a great year for AccessData's enterprise-class products as well.
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