competitive antagonist


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com·pet·i·tive an·tag·o·nist

an antimetabolite.
References in periodicals archive ?
MK-801 (a use-dependent channel blocker or uncompetitive antagonist) and CGP 37849 (a competitive antagonist) have shown antidepressant properties in preclinical studies, either alone or combined with traditional antidepressants.[12,13]
Ginger is a competitive antagonist for H3 receptors and it has clinical effect a few days after treatment for approximately 80% of women.
It acts as a competitive antagonist of growth hormone releasing hormone at its receptor in pituitary and immune cells12.
Neostigmine acts as a competitive antagonist at the neuromuscular junction by increasing the level of acetocholine available for binding to nicotinic receptors.
Like zafirlukast, montelukast is a competitive antagonist for the cysteinyl leukotrienes.
Icatibant is a selective competitive antagonist of the bradykinin [[beta].sub.2], receptor.
Pregnenolone has also been demonstrated to partially protect against memory deficits, induced by the administration of an N-Methyl-D-aspartale (NMDA) receptor competitive antagonist. (12) These receptors play key roles in learning and memory, (13),(14),(15) in excitatory synaptic transmission, (16) as well as in the central regulation of bodily functions.
Exposure to 10 [micro]M SB-710411 causes a significant shift in the agonist concentration-response curve with no suppression of the [E.sub.max], suggesting that it acts as a competitive antagonist. In contrast, SB-710411 did not alter the contractile efficacy of angiotensin-II, phenylephrine, or KCl, although it potentiated the contractile response to endothelin-1 in the isolated rat aorta.
Together, these findings give indirect evidence for the idea that PA could be a potent competitive antagonist of P2Y12 receptor, and open the possibility to consider it as new member of the non-nucleotide generation of antiplatelet drugs.
Flumazenil is a competitive antagonist at the benzodiazepine receptor with duration of action varying from 140 to 250 minutes.
The IL-1 family (8) comprises 3 members: IL-1A and IL-1B, which act as proinflammatory agonists, and their competitive antagonist, the IL-1 receptor antagonist (IL-1RA).
NK4 is an elastase-generated fragment of hepatocyte growth factor (HGF) containing four kringle domains, initially discovered as a competitive antagonist of HGF.