compartment model

compartment model

[kəmpärt′mənt]
a mathematic representation of the body or an area of the body created to study physiological or pharmacological kinetic characteristics. A compartment model can simulate all of the biological processes involved in the kinetic behavior of a drug after it has been introduced into the body, leading to a better understanding of its pharmacodynamic effects. Studies most frequently use one- or two-compartment models. In a one-compartment model the body assumes the characteristics of a homogeneous unit in which an administered drug diffuses instantaneously in the volume of body fluid. In a two-compartment model the body is represented as two distinct compartments, a central and a peripheral compartment, with two separate fluid volumes.
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These models included basal cAMP production, cAMP hydrolysis, and the two compartment model included a simplified description of the spatial spread of cAMP signals.
We first sought to assess the ability of MP-mediated increases in cytosolic cAMP levels to activate downstream cAMP effectors using a one compartment model.
By adopting a single-zone smoke it was assumed that polymer materials would burn in a compartment model with a capacity of 114.
The single zone model may be applied for needs of making an initial assessment of the impact of a fire retardant on the smoke logging degree of a compartment model.
Calculation of the AUC can be done by compartment model or on the basis of a noncompartment calculation.
The two conceptual models compared were a mechanistic model based on the Richards equation for saturated--unsaturated water flow, and a compartment model that includes simplified schemes for redistribution of water in the soil.
The second model is a budget or compartment model, which represents a significant simplification over the mechanistic model both in terms of model equations and in numerical scheme.
One model Fiber-Lite can be carried on a trailer hitch while another stacked six compartment model slides into the bed of a standard size pickup.
We have previously described the validation of a nine compartment model of anaesthetic uptake and distribution with isoflurane and sevoflurane (1).
The compartment model was also used to evaluate important parameters that define the uptake of the compounds of interest.
Raw data were analyzed as a function of time with one and two compartment models using the naive-pooled data approach (Ette & Williams 2004) and WinNonlin 5.
Based on MGA's powerful simulation language ACSL (Advanced Continuous Simulation Language), ACSL BioMed helps researchers better understand the complex relationships between variables such as study design, dosing schemes, sample approach and biological compartment models.

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