compartment model

compartment model

[kəmpärt′mənt]
a mathematic representation of the body or an area of the body created to study physiological or pharmacological kinetic characteristics. A compartment model can simulate all of the biological processes involved in the kinetic behavior of a drug after it has been introduced into the body, leading to a better understanding of its pharmacodynamic effects. Studies most frequently use one- or two-compartment models. In a one-compartment model the body assumes the characteristics of a homogeneous unit in which an administered drug diffuses instantaneously in the volume of body fluid. In a two-compartment model the body is represented as two distinct compartments, a central and a peripheral compartment, with two separate fluid volumes.
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Pharmacokinetics of morphine and fentanyl was simulated by the three compartment model.
2012), an effect compartment model was used to explain the asynchrony between the plasma concentration and the pharmacological effect.
The results presented here are an important step in constructing a compartment model that captures the fundamental properties of in vivo tumor growth.
In this paper we showed that the numerical results obtained from the non-standard compartment model converge to the numerical results of the spatially distributed model where the numerical results of the latter model have earlier been validated against in-vitro experimental results.
These models included basal cAMP production, cAMP hydrolysis, and the two compartment model included a simplified description of the spatial spread of cAMP signals.
Calculation of the AUC can be done by compartment model or on the basis of a noncompartment calculation.
The two conceptual models compared were a mechanistic model based on the Richards equation for saturated--unsaturated water flow, and a compartment model that includes simplified schemes for redistribution of water in the soil.
Analysis of model diagnostics favoured selection of the three compartment model.
The pharmacokinetics (PK) of Ketoprofen in donkeys was best fitted to two compartment model.
The basic theoretical model of body composition is the two compartment model (2C).
Agilent instrumentation used was the 1290-Binary Pump Model G4220A, the 1290-ALS Model G4226A, the 1290-Column Compartment Model G1316C and the Sampler Thermostat.

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