comparative genomic hybridization


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comparative genomic hybridization

a cytogenetic technique in which reference DNA and the DNA to be studied, as from a tumor or an embryo, are labeled with green- and red-fluorescing fluorochromes, respectively. Genetic abnormalities are detected by changes in the green-to-red ratio.
References in periodicals archive ?
Molecular cytogenetic analysis of uterine leiomyoma and leiomyosarcoma by comparative genomic hybridization.
Application of a simplified comparative genomic hybridization technique to screen for gene amplification in pediatric solid tumors.
Chromosome analysis of blastomeres from human embryos by using comparative genomic hybridization.
Development of a focused oligonucleotide-array comparative genomic hybridization chip for clinical diagnosis of genomic imbalance.
The scope of cytogenetics includes several technologies besides fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH), and multicolor FISH.
In addition, the gains and losses in the specific chromosome regions were identified by comparative genomic hybridization (CGH) and the amplifications of cancer-related genes were also detected by polymerase chain reaction (PCR).
Significant advances have been made in microarray technology, particularly for diagnostic testing in prenatal screening, (1) including bacterial artificial chromosome (BAC) clone arrays, oligonucleotide array comparative genomic hybridization (oligo aCGH), and single nucleotide polymorphism (SNP) chips.
The GenetiSure Pre-Screen array is based on Agilent's market-leading technology for high-resolution oligonucleotide comparative genomic hybridization.
There are 2 basic array types--one that originated from the comparative genomic hybridization (CGH) technique and the other from the single-nucleotide polymorphism (SNP) genotyping array.
This dichotomy in chromosomal copy number aberrations between benign and malignant tumors was efficiently exploited in 1992 with the introduction of a novel technique known as comparative genomic hybridization (CGH).
Array-based comparative genomic hybridization (aCGH) makes it possible to assess the chromosome count and perform a high-resolution search for microduplications and deletions.
We are delighted to announce the world's first pregnancy using real time polar body array Comparative Genomic Hybridization (CGH) and the baby is due later in the spring," the Telegraph quoted Dr Simon Fishel, from the Care Fertility Group in Nottingham, as saying.
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