common pathway


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common pathway

Any final route in a molecular 'cascade' in which there is a complex interplay among enzymes, substrates, activators, inactivators, and a relatively small signal is 'amplified' by a positive feedback loop to produce an effect Coagulation A CP is initiated by either the extrinsic or intrinsic pathway, either of which activates factor X–Xa, which in turn activates factor II, converting it into thrombin in the presence of factor V, Ca2+, and membrane phospholipid, and activate prothrombinase producing thrombin from prothrombin; prothrombin then converts fibrinogen into fibrin, forming a blood clot, that becomes irreversible when factor XIII is activated

Common pathway

The pathway that results from the merging of the extrinsic and intrinsic pathways. The common pathway includes the final steps before a clot is formed.
References in periodicals archive ?
[5-8] Prothrombin time is a laboratory screening test used to detect disorders involving the activity of the factors I, II, V, VII, and X of the extrinsic and common pathways .
Surprisingly, there was no common pathway. China relied on a rising economic tide to lift all boats.
Apprenticeship programs are another common pathway, combining classroom and on-the-job experience.
Transcriptomics data integration reveals Jak-STAT as a common pathway affected by pathogenic intracellular bacteria in natural reservoir hosts.
The common pathway is venous outflow obstruction, leading to engorgement and inflammation of the epiploic appendage.
"One common pathway into sex work is the desire to escape from marital life, which represents freedom from violence, humiliation, and dominance from the husband," says Population Council demographer and biostatistician Niranjan Saggurti, lead researcher on the study.
We can now try to achieve a common pathway where veterans are seen by the right people and the right place at the right time."
its response to allergic reactions share a common pathway.
According to research by Cancer Research UK and King's College London - which could lead to more effective cancer treatments - the body's surveillance system for damage caused by cancer and its response to allergic reactions share a common pathway. Researchers unexpectedly discovered that the damage threats, such as smoking, cause to the cells lining the body triggers part of the body's defence system and floods it with antibodies usually linked to an allergic response.
This is the most common pathway. The Reserve has 390 joint duty assignments, though most are in the individual mobilization augmentee world, but ARPC is working to add more positions in the future.
University courses are now the most common pathway into engineering design.
He discusses how experimental leukemia research started and developed, the progress of cancer concepts, early research, research on avian leukosis and sarcoma virus, mouse and rat viruses, studies on stem cells and cytokines, viral and chemical carcinogenesis, cell cycle control and centrosome, important oncogenes and suppressor genes and the related cell biology, skin carcinogenesis, DNA viruses, and the common pathway for retroviruses and chemicals.

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