common pathway

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common pathway

Any final route in a molecular 'cascade' in which there is a complex interplay among enzymes, substrates, activators, inactivators, and a relatively small signal is 'amplified' by a positive feedback loop to produce an effect Coagulation A CP is initiated by either the extrinsic or intrinsic pathway, either of which activates factor X–Xa, which in turn activates factor II, converting it into thrombin in the presence of factor V, Ca2+, and membrane phospholipid, and activate prothrombinase producing thrombin from prothrombin; prothrombin then converts fibrinogen into fibrin, forming a blood clot, that becomes irreversible when factor XIII is activated
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Common pathway

The pathway that results from the merging of the extrinsic and intrinsic pathways. The common pathway includes the final steps before a clot is formed.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
[5-8] Prothrombin time is a laboratory screening test used to detect disorders involving the activity of the factors I, II, V, VII, and X of the extrinsic and common pathways .
Surprisingly, there was no common pathway. China relied on a rising economic tide to lift all boats.
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We can now try to achieve a common pathway where veterans are seen by the right people and the right place at the right time."
its response to allergic reactions share a common pathway.
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University courses are now the most common pathway into engineering design.
He discusses how experimental leukemia research started and developed, the progress of cancer concepts, early research, research on avian leukosis and sarcoma virus, mouse and rat viruses, studies on stem cells and cytokines, viral and chemical carcinogenesis, cell cycle control and centrosome, important oncogenes and suppressor genes and the related cell biology, skin carcinogenesis, DNA viruses, and the common pathway for retroviruses and chemicals.

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