In agenesis of corpus callosum, commissural fibers
do not cross the midline instead thick bundles of intersecting fibers called Probst bundles which lie along the super medial aspect of the lateral ventricles and the third ventricle may sometimes be displaced upward.
Under these conditions, Schaffer commissural fibers were cut between areas CA1 and CA3.
In that line, 2 stimulation pulses were delivered to Schaffer commissural fibers at several interstimulus intervals (50,75,100,150,200, 300, and 400 ms).
They describe the detailed wiring patterns of commissural fibers
connecting the right and left hemispheres of the cerebral cortex, in three dimensions, for the first time.
Aside from corpus callosum, these abnormalities may also reside in commissural fibers
such as anterior and posterior commissure, but less frequently.
By contrast, pontocerebellar projection fibers were particularly resistant to HIV effects, as were commissural fibers
coursing through premotor and sensorimotor callosal sectors (Pfefferbaum et al.
Quantitative analysis of myelinated axons of commissural fibers
in the rat brain.
Also, the PCRF is traversed by an extensive system of commissural fibers
that interconnect the vestibular nuclear complexes.
As pointed out by Pandya and Seltzer "The understanding of the precise topography for commissural fibers allows one to assess the nature of functional deficits following selective commissural lesions and to predict the localization of functions within cerebral commissural systems" .
Seltzer, "The topography of commissural fibers," in Two Hemispheres-One Brain: Functions of the Corpus Callosum, F.