Florid LCIS has been referred to in the literature as macroacinar lobular intraepithelial neoplasia (18) and LCIS with comedonecrosis
(19) The designation florid is applied to cases of LCIS with the marked ductal and lobular expansion by LCIS cells of low to intermediate nuclear grade (Figure 4, B).
Points are scored for the histological pattern, tumour cellularity, comedonecrosis
, vascular or capsular invasion, Ki-67 labeling, and catecholamine subtype.
Lesions that show marked nuclear pleomorphism, with or without apocrine features and comedonecrosis
are referred as pleomorphic LCIS (PLCIS).
A): Dynamic contrast- enhanced image disclosed a ring-like tumor focus; B): Enhancement rate 230%; C): Ascending enhancing mode and dynamic contrast-enhanced curve; D and E): Optical microscopic observation showed comedonecrosis
(white arrow) and fibrosis (black arrow) (HEA-100).
and a young age at diagnosis, reported by others to be also associated with histological upgrade, were not found significant in our study [25, 28].
They feature large ducts with solid, papillary, and comedonecrosis
areas (figure 1).
The latter may appear as nests of basal-type cells with scanty cytoplasm, central comedonecrosis
, and peripheral palisading.
17) The architectural pattern of IDCP includes solid growth, a dense cribriform or micropapillary pattern with marked nuclear atypia, and occasional comedonecrosis
A high number of mitotic figures is present, and the tumor shows extensive coagulative necrosis with areas of central comedonecrosis
2) The most commonly used contemporary definition of IDC-P is by Guo and Epstein, (52) requiring an intraductal growth with either: (1) solid pattern; (2) dense cribriform morphology, defined as greater than 70% epithelium as opposed to lumens; or (3) loose cribriform and/or micropapillary lesions with either marked nuclear atypia (6X normal) or comedonecrosis
(Figure 3, E and F).
True tumor comedonecrosis
suggests malignancy (figure 2, B).
Leal et al (18) classified apocrine DCIS into low, intermediate, and high grade based on nuclear criteria and the presence of comedonecrosis