combined immunodeficiency

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com·bined im·mu·no·de·fi·cien·cy

immunodeficiency of both B and T lymphocytes.

com·bined im·mu·no·de·fi·cien·cy

(kŏm-bīnd' im'yū-nō-dĕ-fish'ĕn-sē)
Immunodeficiency of both the B-lymphocytes and T-lymphocytes.


a deficiency in the immune system, either that mediated by antibody or T lymphocytes, or both. See also agammaglobulinemia, hypogammaglobulinemia, feline immunodeficiency virus, bovine immunodeficiency virus.

acquired immunodeficiency
see immune deficiency disease.
cancer-associated immunodeficiency
in general, associated with cachexia and debilitation, and also related to the type of neoplasia. Tumor-related effects on the immune system include impaired function of lymphocytes, altered cytokine production and activation of suppressor cell functions.
combined immunodeficiency
common variable immunodeficiency
a term encompassing a heterogeneous group of syndromes, which may be inherited or acquired, characterized by recurring persistent infections and deficiencies of some of the immunoglobulin classes.
congenital immunodeficiency
see immune deficiency disease.
immunodeficiency disease
iatrogenic immunodeficiency
secondary immune deficiency disease.
severe combined immunodeficiency
X-linked immunodeficiency
an inherited form of severe combined immunodeficiency has been reported in dogs. Puppies fail to grow and die from overwhelming infections at an early age.
References in periodicals archive ?
We believe that patients with severe combined immunodeficiency and any form of mild local changes at the BCG injection site should be given single or double anti-TB therapy, which should be continued until complete immunologic reconstitution occurs after bone marrow transplant.
Orphan Europe works with the following diseases: acute porphyria, congenital sucrase-isomaltase deficiency, homocystinuria, hyperammonaemia due to NAGS deficiency, nephropathic cystinosis, patent ductus arteriosus, severe combined immunodeficiency - adenosine deaminase deficiency, vitamin E deficiency in chronic cholestasis and Wilson's disease.
If so, it will be the first time British doctors have successfully corrected the gene defect that causes Severe Combined Immunodeficiency Disorder (SCID).
So far diseases such as leukaemia, non-Hodgkins lymphoma and Severe Combined Immunodeficiency have been treated in this way.
Disseminated Mycobacerium marinum infection and bacteremia in a child with severe combined immunodeficiency.
T-B+NK+ severe combined immunodeficiency caused by complete deficiency of CD3f subunit of the T-cell antigen receptor complex.
A US government health panel has recommended that 2 US gene therapy trials involving children with X-linked severe combined immunodeficiency (X-SCID) be allowed to resume but only on a limited basis.
Combined immunodeficiency associated with DOCK8 mutations and related immunodeficiencies.
The findings also may have implications for treating illnesses associated with loss of infection-fighting cells, such as HIV and severe combined immunodeficiency disease, better known as bubble boy disease.
Brother and sister Andrew and Caitlin Scullion were born with the life-threatening genetic condition, Severe Combined Immunodeficiency Disorder.
The charity helps children diagnosed with Severe Combined Immunodeficiency (SCID), born with a gene deficiency that means they can not fight infection and other primary immunodeficiencies.

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