combinatorial library

combinatorial library

A collection of chemical compounds, so designated because it has so many structures and variants that special methods are needed to catalogue, store and retrieve individual units—as in a real library.

Combinatorial libraries can exist as molecules free in solution linked to a solid substrate (e.g., a bead), or arranged on the surface of a microorganism. They are created either by split synthesis or parallel synthesis.
References in periodicals archive ?
In the hyphenated nuclear magnetic resonance spectrometer market, application of HPLC-NMR-MS is of prime importance in drug discovery, particularly in structure elucidation and separation of drug impurities, reaction mixtures, in vitro and in vivo metabolites, degradation products and combinatorial library samples.
[sup][20] In this method, a solid-phase combinatorial library of hexapeptides is coupled, via a short spacer, on poly (hydroxymethecrylate) beads, by a modified Merrifield approach.
During the past decades, Creative Biomart has always been devoting to innovate product quality and production techniques and many achievements have been gained, for example, its BacTECTM and FoldEZTM technological platform to express tricky proteins, its GenePowerTM technology to create genetic variants for research purpose, its GenePowerTM Combinatorial Library Lipid-based Protein immobilization technology to immobilize native membrane proteins in the form of proteoliposomes, generated directly from cells or tissue and so many others.
Using a combinatorial library of synthetic "shape" molecules, they screened for ligands that bind antibodies in the serum of individuals with the target condition but that do not bind antibodies in the serum of individuals without the target condition.
The combinatorial chemistry asset, which Ligand obtained in the acquisition of Pharmacopeia in December 2008, comprises an encoded combinatorial library collection (ECLiPS) and an ultra-high throughput screening platform.
"A Combinatorial Library of Photocrosslinkable and Degradable Materials." Adv.
The columns are suited for high-throughput purifications where impure samples and abusive ballistic gradients are encountered, such as in combinatorial library purifications.
The license includes approximately 10 issued patents and several patent applications as well as use of a combinatorial library of 114 polymers with a range of physical properties.
High throughput methods are the companion techniques that use a sequential process to evaluate or measure the properties of samples in the combinatorial library.
Combinatorial library design software, for example, might account for the availability of starting materials for a synthesis.
To explore the effect of acrylic polyol composition on the physical, mechanical, and performance properties of the self-stratifying siloxane-polyurethane coatings, a combinatorial library was prepared using three monomers to vary the acrylic polyol composition, HEA, BA, and BMA.

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