combinatorial chemistry


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combinatorial chemistry

The branch of chemistry in which a few basic molecules are combined in various ways to yield a large number of different products; often undertaken in pharmaceutical research.

combinatorial chemistry

The science of creating chemical diversity, a chemistry-based platform for systematically assembling known chemical entities—molecular building blocks—in as many different combinations as possible, generating millions of new screenable compounds for rapid drug discovery. The strategy is to assemble every possible combination of a given set of chemical building blocks while simulataneously recording which ones have been used and in what order, then assay the resulting molecules at once and refer to the record to determine the identity of any that look promising.

Drugs developed by traditional synthetic chemistry require an average of 12 years to identify, while combinatorial compounds of potential interest may be identified within a month; most compounds thusfar created are peptides and oligonucleotides. In the pharmaceutical industry, combinatorial “libraries” of millions of compounds may be produced by smaller biotechnology companies, which may be purchased in part or their entirety by larger companies seeking leads for newer therapeutic agents.
 
Phases, CC research
Synthesis, distribution, inventorying, screening.

combinatorial chemistry

The manufacturing of molecules having specific sizes, shapes, or functional characteristics using computer-aided algorithms or design rules.
See also: chemistry
References in periodicals archive ?
Note: I would be pleased to send any interested reader the patent references from the Maro Collection for Combinatorial Chemistry.
The increasing complexity of combinatorial chemistry procedures and related measurements will boost opportunities for complementary software.
The application of combinatorial chemistry to agricultural research can speed laboratory research by several days and can aid scientists in determining optimum conditions before beginning large-scale processes.
The pioneering effort for combinatorial chemistry has now shifted to these other industries, many of which are showing signs of rapidly warming to combinatorial chemistry.
The combinatorial chemistry process is the natural culmination of several evolving technologies - robotics, computer control and tracking, molecular modeling, and high-speed database search tools - together reaching a sort of critical mass.
for example, has a research and development pact with Pharmacopeia in which the latter will provide combinatorial chemistry support for several Sandoz drug discovery programs.
He has authored and co-authored numerous scientific papers as well as written a textbook on Combinatorial Chemistry.
Researchers are now combining combinatorial chemistry methodologies with nanotechnology to develop novel smart materials with higher performance standards.
To achieve this acceleration of the processes, chemical genomics/chemogenomis integrates the latest developments in tools and technologies from a variety of disciplines; including combinatorial chemistry, informatics, synthetic chemistry, cell-based assays, microarrays, genomics, bioinformatics, toxicogenomics, and proteomics.
It is an internationally recognized research center in the field of combinatorial chemistry.
This 'one-beaker' process aims at simplifying the synthesis of designer polymers through self-assembly using combinatorial chemistry.

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