combinatorial biology

combinatorial biology

an approach involving the use of RECOMBINANT DNA techniques to manipulate organisms, such as BACTERIA and FUNGI, that produce complex natural products. The technology includes the creation of large libraries (with many different genetic combinations) of recombinant microorganisms that generate new organic molecules and the manipulation of metabolic pathways to modify valuable microbial metabolites. Combinatorial biology is providing opportunities in, for example, novel drug discovery. See also PHAGE DISPLAY LIBRARY.
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San Francisco, CA; 650-624-1246) announced that a new study published in the current issue of Nature Genetics (volume 27, no.1, January 2001) demonstrates the utility of the company's combinatorial biology technology in rapidly and efficiently identifying novel, functional drug targets in important disease signaling pathways.
"Our combinatorial biology technology, which offers the first demonstration of a practical way to get at large-scale functional genomics in mammalian systems, provides a functional means to identify potential drug-target candidates as well as a biological understanding of human cellular disease mechanisms.
The Nature Genetics study and accompanying editorial reports Rigel's success in applying its combinatorial biology technology to the emerging clinical problem of resistance to the anti-cancer drug, Taxol, to demonstrate proof-of-principle of this novel approach to functional genomics.
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