for patients with type 2 diabetes is a safe and effective stepping stone between oral therapy and insulin therapy Unfortunately, significant barriers remain to getting insulin started when oral agents alone are insufficient.
Adverse events occurred with equal frequency in both groups, but significantly more patients on combination therapy
(85%) finished the trial, compared with patients on donepezil monotherapy (75%).
None of the 72 women studied who had an elective cesarean and received combination therapy
transmitted HIV to their infants, compared with 2 of 90 (2%) women who received combination therapy
and delivered vaginally; One of 22 (5%) women who had elective cesareans and received monotherapy transmitted HIV to her infant, compared with 4 of 52 (8%) women who delivered vaginally and received monotherapy.
The experiments were the first to find the virus hidden in the immune system in patients with undetectable levels of HIV in their blood, and the first to show that the virus did not become drug resistant in people who were responding well to combination therapy
This study suggests that the results of combination therapy
will be maintained for a period of time with Oracea alone.
Based on data from the closed triple combination therapy
development programme, the submission including data from the phase III FULFIL study, as well as data from studies with FF, UMEC and VI either alone or in combination.
With more reports, we hope that physicians will be more willing to use combination therapy
and use it as first-line therapy," he said.
The company stated the closed triple combination therapy
comprises three medicines: fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist (LAMA) and vilanterol, a long- acting beta2-adrenergic agonist (LABA), delivered once-daily in GSK's Ellipta[R] dry powder inhaler.
M2 PHARMA-November 22, 2016-GSK announces regulatory filing once-daily closed triple combination therapy
FF/UMEC/VI for patients with COPD
The week-16 PASI-100 rate of 24% with monotherapy also was significantly better than the 15% with combination therapy
Also, patients who achieve remission on initial combination therapy
are 10 times less likely to show significant radiographic progression of joint damage than those who are started on monotherapy and achieve remission, according to the investigators for BeSt, a Dutch acronym for Behandel Strategieen, meaning treatment strategies.
It might not be advisable to switch to a new combination therapy
if viral load tests and CD-4 counts show that a patient is doing well.