combination therapy


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combination therapy

Pharmacology Cocktail therapy The use of multiple agents to treat a clinical condition–eg, cancer, AIDS Reproductive medicine The use of estrogen and progestin as an OC. Cf Chemotherapy, Combined modality therapy, Polypharmacy.

combination therapy

Treatment, especially for cancer, in which various different modalities, such as surgery, radiotherapy or chemotherapy, are used together or sequentially.
References in periodicals archive ?
Around 7,500 people in England are diagnosed each year with this type of lung cancer, of whom approximately 1,700 may be eligible for pembrolizumab combination therapy.
However, risk estimates revealed that a patient treated with mono therapy had lesser chances of stone expulsion (RR: 0.812; 95% CI: 0.688-0.960) compared to that of combination therapy (p = 0.02).
Hence further studies are needed to study the safety profile of synthetic DMARDs so that we employ this combination therapy frequently in our patients.
In the present study, it was found that monotherapy was mostly prescribed in the beginning or mild to moderate hypertensive patients while combination therapy was mostly prescribed in patients who have not controlled with single drug therapy on in the case of moderate to severe hypertensive patients.
This first regulatory submission of our closed triple combination therapy brings us a step closer to providing a once-daily treatment in a single Ellipta inhaler as an alternative option for those patients who require multiple therapies."
The arguments in favor of combination therapy are that a single agent may have limited efficacy, multiple metabolic abnormalities contribute to hyperglycemia, drugs with complementary mechanisms of action will work better, and getting to an [HbA.sub.1c] goal faster will improve outcomes.
Table-1: Efficacy, safety and cost parameters of fixed dose combination therapy.
By the end of the studies, the mean score among those with NPI scores of 1-3 who took combination therapy actually had improved significantly from baseline (about 0.5 points).
The smoking abstinence rates were no longer significantly different between the two groups at 1 year: 30.9% with combination therapy, compared with 24.5% with vareni-dine alone.
The combination therapy particularly benefitted heavy smokers.
Switching to fixed combination therapy from PG monotherapy, the mean IOP was 13.1 [+ or -] 1.79 mmHg (P < 0.001) (-24.71% reduction from baseline) at 6 months.
5ARIs, administered as monotherapy or in combination with alpha-blockers, are recommended for symptomatic men with an enlarged prostate and are associated with decreased risk of urinary retention and/or prostate surgery.[sup.7] The guidelines also state that combination therapy effectively delays symptomatic disease progression.[sup.7]