Response to injury could also explain the IND-like hyperplasia of submucosal ganglia observed in intestinal allografts (47) and fibrosing colonopathy
Moreover, these investigators found that esophageal varices [greater than or equal to] grade 2, portal gastropathy, portal colonopathy, and Child-Pugh class C cirrhosis were all significantly associated with PHE.
Upper GI endoscopy and colonoscopy were performed independently, and the presence or absence of esophageal varices (EV), gastric varices (GV), portal hypertensive gastropathy (PHG), and portal hypertensive colonopathy (PHC) was determined.
Patients who take more than 6,000 lipase units/kg of body weight per meal (or 10,000 lipase units/kg of body weight/day) are at risk for developing fibrosing colonopathy
, a type of stricture of the colon (Medscape, 2016; Vallerand et al., 2015).
The main drawback of PPIs is that they are less effective against mucosal injury in more distal parts of the intestine like NSAID-induced colonopathy
(52) Because of the possible risk of fibrosing colonopathy
with very high doses of enzyme replacement, a ceiling of 75 000 IU of lipase per meal has been recommended by some.
Solvay will also be required to conduct a 10-year observational study to evaluate the incidence of fibrosing colonopathy
in cystic fibrosis patients treated with Creon, and to evaluate the risk of transmission of selected porcine viruses in treated patients, according to the FDA approval letter.
Pancreatic enzyme supplementation in cystic fibrosis patients before and after fibrosing colonopathy. J Pediatr Gastroenterol Nutr 1998; 26: 80-4.
High dose pancreatic enzyme supplements and fibrosing colonopathy in children with cystic fibrosis.
The incidence of fibrosing colonopathy, associated with high doses of pancreatic enzymes and/or the use of high strength preparations in the early 1990s (7-9), caused many centres treating CF to review the practices of their patients and collaborate to produce national guidelines (4,10,11).
Individuals with CF and their parents were advised against self-adjusting the dose in the 1990s when fibrosing colonopathy was identified by other centres.