aganglionosis

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Related to colonic aganglionosis: congenital aganglionic megacolon

aganglionosis

 [ah-gang″gle-on-o´sis]
congenital absence of parasympathetic ganglion cells, such as in congenital megacolon.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

a·gan·gli·o·no·sis

(ā-gang'glē-ō-nō'sis),
The state of being without ganglia; for example, absence of ganglion cells from the myenteric plexus as a characteristic of congenital megacolon.
[G. ā- priv. + ganglion + -osis, condition]
Farlex Partner Medical Dictionary © Farlex 2012

a·gan·gli·o·no·sis

(ā-gang'glē-ŏ-nō'sis)
The state of being without ganglia; e.g., absence of ganglion cells from the myenteric plexus as a characteristic of congenital megacolon.
[G. ā- priv. + ganglion + -osis, condition]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Total colonic aganglionosis and Hirshsprung's disease: shades of the same or different?
Clinical and genetic differences in total colonic aganglionosis in Hirschsprung's disease.
[4] Nonstandard abbreviations: HSCR, Hirschsprung disease; SSA, short-segment aganglionosis; LSA, long-segment aganglionosis; ENS, enteric nervous system; RET, receptor tyrosine kinase; EDNRB, endothelin receptor B; GDNF, glial cell-line-derived neurotrophic factor; EDN3, endothelin 3; TCA, total colonic aganglionosis; CCHS, congenital central hypoventilation syndrome; CD, cadherin domain; TK, tyrosine kinase; and SNP, single-nucleotide polymorphism.
* Total colonic aganglionosis or TCA--Aganglionotic segment extends from the anal canal to at least the ileocaecal valve, doesn't extend proximal bowel beyond 50 cm of the ileocaecal valve.
(17) Solari et al in his report had remarked about the lack of myenteric interstitial cell of Cajal in the smooth muscle layer and a reduced hypertrophied nerve trunk in total colonic aganglionosis. (18) Hence,this condition is very difficult to diagnose.
In the 2 cases of total colonic aganglionosis, GLUT-1 fibers were not found in the submucosa, although multiple sections from different regions were examined.