' gradin'-camp drivers an' mule-skinners all up an' down the state.
I'm not a tipplin' man nor a drunkard-- nobody can say it on me--but I like a extry quart at Easter or Christmas time, as is nat'ral when we're goin' the rounds a- singin', an' folks offer't you for nothin'; or when I'm a- collectin
' the dues; an' I like a pint wi' my pipe, an' a neighbourly chat at Mester Casson's now an' then, for I was brought up i' the Church, thank God, an' ha' been a parish clerk this two-an'-thirty year: I should know what the church religion is."
SP-D is one of the four members of collagenous subfamily of calcium-dependant lectins (collectins
Structural aspects of collectins
and receptors for collectins
, Immunobiology, 1998, 165-189.
MBL belongs to the subgroup of collectins
in the C-type lectin superfamily that acts as the first defense by taking up pattern recognition proteins participating in the innate immune response .
Various lectins serve as PRRs in innate immune responses against pathogens, including soluble molecules such as collectins
and ficollins , as well as membrane receptors like the members of the C-type lectin family .
, such as surfactant protein-A (SP-A) and SP-D are also involved in innate immunity.
Studies in sheep, for example, find that in utero ethanol disrupts immune function by decreasing in the fetal lung surfactant proteins (SP), which also are known as collectins
, particularly SP-A and SP-D (Lazic et al.
Innate immunity consists of a highly regulated immune surveillance system comprising several humoral factors, including soluble PRRs, such as collectins
, ficolins, and pentraxins [32, 33], and the complement cascade .
The authors showed that chimeric proteins contain complementary portions of two collectins
(MBL, surfactant protein D, or bovine serum conglutinin) or one collection (surfact protein D) fused to anti-CD89 (an anti Fc-[alpha] RI).
Heritability estimates for the constitutional levels of the collectins
mannan-binding lectin and lung surfactant protein D.