They're
collectin' gradin'-camp drivers an' mule-skinners all up an' down the state.
I'm not a tipplin' man nor a drunkard-- nobody can say it on me--but I like a extry quart at Easter or Christmas time, as is nat'ral when we're goin' the rounds a- singin', an' folks offer't you for nothin'; or when I'm a-
collectin' the dues; an' I like a pint wi' my pipe, an' a neighbourly chat at Mester Casson's now an' then, for I was brought up i' the Church, thank God, an' ha' been a parish clerk this two-an'-thirty year: I should know what the church religion is."
SP-D is one of the four members of collagenous subfamily of calcium-dependant lectins (
collectins).
Structural aspects of
collectins and receptors for
collectins, Immunobiology, 1998, 165-189.
MBL belongs to the subgroup of
collectins in the C-type lectin superfamily that acts as the first defense by taking up pattern recognition proteins participating in the innate immune response [71].
Various lectins serve as PRRs in innate immune responses against pathogens, including soluble molecules such as
collectins and ficollins [38], as well as membrane receptors like the members of the C-type lectin family [39].
Collectins, such as surfactant protein-A (SP-A) and SP-D are also involved in innate immunity.
These include complement components,
collectins, ficolins, and pentraxins.
Studies in sheep, for example, find that in utero ethanol disrupts immune function by decreasing in the fetal lung surfactant proteins (SP), which also are known as
collectins, particularly SP-A and SP-D (Lazic et al.
Innate immunity consists of a highly regulated immune surveillance system comprising several humoral factors, including soluble PRRs, such as
collectins, ficolins, and pentraxins [32, 33], and the complement cascade [34].
The authors showed that chimeric proteins contain complementary portions of two
collectins (MBL, surfactant protein D, or bovine serum conglutinin) or one collection (surfact protein D) fused to anti-CD89 (an anti Fc-[alpha] RI).
Heritability estimates for the constitutional levels of the
collectins mannan-binding lectin and lung surfactant protein D.
