' gradin'-camp drivers an' mule-skinners all up an' down the state.
I'm not a tipplin' man nor a drunkard-- nobody can say it on me--but I like a extry quart at Easter or Christmas time, as is nat'ral when we're goin' the rounds a- singin', an' folks offer't you for nothin'; or when I'm a- collectin
' the dues; an' I like a pint wi' my pipe, an' a neighbourly chat at Mester Casson's now an' then, for I was brought up i' the Church, thank God, an' ha' been a parish clerk this two-an'-thirty year: I should know what the church religion is."
SP-D is one of the four members of collagenous subfamily of calcium-dependant lectins (collectins
Structural aspects of collectins
and receptors for collectins
, Immunobiology, 1998, 165-189.
MBL belongs to the subgroup of collectins
in the C-type lectin superfamily that acts as the first defense by taking up pattern recognition proteins participating in the innate immune response .
Various lectins serve as PRRs in innate immune responses against pathogens, including soluble molecules such as collectins
and ficollins , as well as membrane receptors like the members of the C-type lectin family .
, such as surfactant protein-A (SP-A) and SP-D are also involved in innate immunity.
These include complement components, collectins
, ficolins, and pentraxins.
Studies in sheep, for example, find that in utero ethanol disrupts immune function by decreasing in the fetal lung surfactant proteins (SP), which also are known as collectins
, particularly SP-A and SP-D (Lazic et al.
Innate immunity consists of a highly regulated immune surveillance system comprising several humoral factors, including soluble PRRs, such as collectins
, ficolins, and pentraxins [32, 33], and the complement cascade .
The authors showed that chimeric proteins contain complementary portions of two collectins
(MBL, surfactant protein D, or bovine serum conglutinin) or one collection (surfact protein D) fused to anti-CD89 (an anti Fc-[alpha] RI).
Heritability estimates for the constitutional levels of the collectins
mannan-binding lectin and lung surfactant protein D.