or calreticulin/CD91, lung
collectins act as dual function surveillance molecules to suppress or enhance inflammation.
Collectins, such as surfactant protein-A (SP-A) and SP-D are also involved in innate immunity.
Collectins and collectin receptors in innate immunity.
These include complement components,
collectins, ficolins, and pentraxins.
Studies in sheep, for example, find that in utero ethanol disrupts immune function by decreasing in the fetal lung surfactant proteins (SP), which also are known as
collectins, particularly SP-A and SP-D (Lazic et al.
Heritability estimates for the constitutional levels of the
collectins mannan-binding lectin and lung surfactant protein D.
Studies have been undertaken to evaluate the association between endometrial and placental expression of immunoregulatory molecules such as
collectins and recurrent spontaneous abortions and pre-term labor.
Collectins and ficolins: humoral lectins of the innate immune defense.
Although
collectins can be immunomodulatory for adult alveolar macrophages (Hickling et al.
We hypothesized that the degree of glycosylation of influenza viruses is inversely related to virulence in a naive host due to glycosylation allowing easier clearance by
collectins.
Among such proteins are lung surfactant proteins A and D, also known as
collectins, or collagen-like domain and calcium-dependent lectin domain proteins (Crouch and Wright 2001).
Serum surfactant protein is a hydrophilic protein from the
collectin family, secreted by alveolar epithelial type 2 and Clara cells in the lung tissue (6).
