G: As the collecting duct
travels down through the medulla of the kidney, it encounters the same hypertonic environment as in the loop of Henle.
The second group comprises the less common types: collecting duct
carcinoma, multilocular cystic renal neoplasm of low malignant potential, mucinous tubular spindle cell carcinoma, acquired cystic disease-associated RCC, and tubulocystic RCC.
The cortical collecting duct
(CCD), the outer medullary collecting duct
(OMCD) and the inner medullary collecting duct
(IMCD) are very important portion of final water reabsorbtion in the animals through AQP2, 3 and 4 (Terris et al., 1995, 1996).
AVP increases water permeability in the renal collecting ducts
by activating arginine vasopressin receptor 2 (AVPR2), one of the family of G protein-coupled receptor, located on the basolateral membrane of the kidney collecting duct
More than 20 types of cancer have been treated in this trial, including Merkel cell, parotid gland, colorectal, endometrial, ER+ and triple-negative breast cancer, esophageal, collecting duct
carcinoma, ovarian, Hodgkin's disease, hemangioepithelioma and other cancers.
ADH activates AQP-2 to be inserted on the luminal side as well AQP-3 and AQP-4 on the serosal side of the collecting duct
Only six cases of tubulocystic carcinoma that derived from the bile duct have been reported as subtype of the collecting duct
carcinoma of the kidney in abstracts of the 102nd United States and Canadian Academy of Pathology (USCAP) annual meeting in 2013, and the details of the entity are unknown.
Subtypes of renal carcinoma include clear cell, papillary, chromophobe, medullary, and collecting duct
Histopathologic examination of the kidneys revealed multifocal mildto-moderate dilation and epithelial hyperplasia of collecting ducts
. Renal collecting duct
epithelial cells contained intracytoplasmic microgametocytes, macrogametocytes, and sporulating and sporulated oocysts.
One case each of collecting duct
carcinoma and RCC with oncocytic features was encountered.
According to the company, ADV7103 has the potential to become the first medicine to address dRTA, a disease that leads to an unbalanced pH in the body as a result of failed acid secretion by the alpha intercalated cells of the cortical collecting duct
of the distal nephron.
Distal Renal Tubulopathy Acidosis (dRTA) is a disease characterised by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct
of the distal nephron.