collapsin

collapsin

(kō-laps'in),
A secreted protein found in bird and rat embryos that collapses the growth cone of axons originating in spinal ganglia. Thought to pattern sensory projections from the ganglia by selectively repelling certain axons so that they terminate dorsally.
Synonym(s): semaphorin III
References in periodicals archive ?
Background: Collapsin response mediator protein-2 (CRMP2) has been shown to be involved in ischemia/hypoxia (IH) injury.
Amyloid-pS6_36 induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2.
In our study patients in the MTLEHS group were drug-resistant, as it was expected, but we did not search for other neural autoantibodies including voltage-gated potassium channel complexes, collapsin response- mediator proteins and Ma2, N-methyl-D-aspartate receptors, and ganglionic acetylcholine receptors.
Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction.
Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat.
3 Target Protects As easy user as possible effectively Design Requirement Parts Characteristic Battery Part Collapsin Charging Travel Customer Requirement Counts Steps Time Range Capability Functional Requirements Collapsible (a) (a) Easy to Use Capable of Long Travel (a) Range Capable of Decelerating and Braking Capable of Pirouetting Ergonomics Requirements Ergonomics High Mobility (a) (a) Comfort Self-Maneuverability (a) Rain Shelter (a) Interface Requirements Convenient Maintenance (a) (b) Design Safety (c) (b) Large Battery Capacity (a) (a) Importance Absolute Weighting 54 43 50 87 Relative Weighting (%) 8.
According to the company Web site, lacosamide has a novel dual method of action, selectively enhancing slow inactivation of voltage-gated sodium channels, and modulating collapsin response mediator protein 2 (CRMP-2).
Collapsin, semaforin, tenassin, konroditin sulfat ve keratan sulfat proteoglikanlarinin yaralanma sahasinda aksonal rejenerasyonu inhibe ettiklerinden suphelenilmektedir (11).
Face collapsin (Ah god, is horrible, I'm old & passing) (Bridget Jones' Diary).
Preclinical studies also suggest that Vimpat([R]) binds to the collapsin response mediator protein-2 (CRMP-2), an important target that affects the way that nerves differentiate and grow.
Background: Collapsin response mediator protein-2 (CRMP2), a multifunctional cytosolic protein highly expressed in the brain, is degraded by calpain following traumatic brain injury (TBI), possibly inhibiting posttraumatic neurite regeneration.
New evidence shows that while collapsin repulses some tips, called growth cones, it attracts others, says Tessier-Lavigne.