collapsin

collapsin

(kō-laps'in),
A secreted protein found in bird and rat embryos that collapses the growth cone of axons originating in spinal ganglia. Thought to pattern sensory projections from the ganglia by selectively repelling certain axons so that they terminate dorsally.
Synonym(s): semaphorin III
References in periodicals archive ?
This enzyme, in turn, blocked another protein called collapsin response mediator protein 2, CRMP2.
Second, LCM binds to collapsin response mediator protein2 (CRMP2), which enhances the drug's antiepileptic activity.
van Aalten et al., "Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression," Journal of Neurochemistry, vol.
PKC appears to also trigger a RhoA-activating cascade through downstream Rho-associated protein kinase (ROCK), which subsequently phosphorylates the collapsin response mediator protein 2 (CRMP-2) and causes growth cone collapse [127] (Figure 2).
Background: Collapsin response mediator protein-2 (CRMP2) has been shown to be involved in ischemia/hypoxia (IH) injury.
Amyloid-pS6_36 induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2.
Moreover, components of the Wnt signaling pathway (dishevelled [18]), cytoskeletal dynamics (e.g., collapsin response mediator protein 2 [19, 2[degrees]]), and innate immunity (e.g., myeloid differentiation primary response 88 (Myd88) [21] and a disintegrin and metalloproteinase 17 (ADAM17) [22]) are regulated by Trx proteins.
Louis, MO, USA); goat anti-rat Nogo-A polyclonal antibody (1:1000, Novusbio, Littleton, CO, USA); rabbit antirat NgR1 polyclonal antibody (1: 1000, Abcam, Cambridge, UK); rabbit anti-rat RhoA monoclonal antibody (1: 1000, Cell Signaling Technology, Boston, MA, USA); rabbit anti-rat ROCK monoclonal antibody (1:1000, Cell Signaling Technology); rabbit anti-rat collapsin response mediator protein 2 (CRMP2) monoclonal antibody (1:1000, Cell Signaling Technology, Boston, MA, USA); rabbit anti-rat pCRMP2 monoclonal antibody (1 : 1000, Cell Signaling Technology).
In our study patients in the MTLEHS group were drug-resistant, as it was expected, but we did not search for other neural autoantibodies including voltage-gated potassium channel complexes, collapsin response- mediator proteins and Ma2, N-methyl-D-aspartate receptors, and ganglionic acetylcholine receptors.
Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction.).
Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat.
In addition, ROCK2 can phosphorylate collapsin response mediator protein 2 (CRMP2), another microtubule associated protein, to induce growth cone collapse [67].