Methods for the treatment of
collagenous tissues for bioprosthesis.
Recent studies show that matrix metalloproteinases and their inhibitors may participate in the alteration of the mechanical properties of mutable
collagenous tissue by controlling the density of linkages between the collagen fibrils (Ribeiro et al., 2012).
Thus it is called mutable
collagenous tissue (MCT) [70] or catch connective tissue [71].
Scars can also lead to nerve impingement and tissue hypoxia, as the blood supply can be restricted by newly formed
collagenous tissue. Another feature to take into account is that skin scar tissue does not contain dermal structures such as sweat glands and hair follicles.
As the quantity of
collagenous tissue increases, the microvessel density often appears to decrease; this is particularly noticeable in comparing Phase 1 and Phase 4 tumors.
Histopathology showed proliferation of stromal connective tissue which surrounded the ductules in a circumferential pattern (pericanalicular type), stroma containing dense fibrous and
collagenous tissue admixed with loose fibroblastic tissue, (Fig.
They are enveloped in a dense fibrous
collagenous tissue sheath constituting the outer layer of the periosteum.
Immunohistochemical staining revealed a light distribution of CD3/CD5-positive T cells within the
collagenous tissue, together with CD68-positive and lysozyme-positive histiocytes.
The resected soft tissue consisted of lobules of well-differentiated adipose tissue surrounding and infiltrating bands of
collagenous tissue (Fig 2).
The
collagenous tissue varied in appearance from relatively dense to quite loose.
A more appropriate name for this condition--based on its location and configuration of accentuated anatomy--is mucogingival papule since the mucogingival papule is a focal elevation of
collagenous tissue at the mucogingival line, overlying the bony prominence that fronts an incisor or cuspid tooth root.
Granulation tissue consisting of adult fibroblasts, neovascularization, dense
collagenous tissue and a moderate polymorphonuclear neutrophil infiltrate was observed at the aponeurotic lesion.
