Methods for the treatment of collagenous tissues
Recent studies show that matrix metalloproteinases and their inhibitors may participate in the alteration of the mechanical properties of mutable collagenous tissue
by controlling the density of linkages between the collagen fibrils (Ribeiro et al., 2012).
Thus it is called mutable collagenous tissue
(MCT)  or catch connective tissue .
Scars can also lead to nerve impingement and tissue hypoxia, as the blood supply can be restricted by newly formed collagenous tissue
. Another feature to take into account is that skin scar tissue does not contain dermal structures such as sweat glands and hair follicles.
As the quantity of collagenous tissue
increases, the microvessel density often appears to decrease; this is particularly noticeable in comparing Phase 1 and Phase 4 tumors.
Histopathology showed proliferation of stromal connective tissue which surrounded the ductules in a circumferential pattern (pericanalicular type), stroma containing dense fibrous and collagenous tissue
admixed with loose fibroblastic tissue, (Fig.
They are enveloped in a dense fibrous collagenous tissue
sheath constituting the outer layer of the periosteum.
Immunohistochemical staining revealed a light distribution of CD3/CD5-positive T cells within the collagenous tissue
, together with CD68-positive and lysozyme-positive histiocytes.
The resected soft tissue consisted of lobules of well-differentiated adipose tissue surrounding and infiltrating bands of collagenous tissue
The collagenous tissue
varied in appearance from relatively dense to quite loose.
Granulation tissue consisting of adult fibroblasts, neovascularization, dense collagenous tissue
and a moderate polymorphonuclear neutrophil infiltrate was observed at the aponeurotic lesion.