MMP-1 enzyme degrades collagen and elastin fibrils, which are important for skin strength and elasticity.
Fassbender (4) defines three different determinants that describe complete picture of RA: exudative inflammatory process, which causes swelling, pain and stiffness; proliferative-destructive process that affects joint destruction; and enzymatic collagenolytic
process, which can cause primary necrotizing of, e.g., myocardial muscle, blood vessels, and sclera of the eye.
CHX also decreases the activity of collagenolytic
enzymes, matrix metalloproteinases (MMPs) in radicular dentin (13, 14), and by that could preserve the collagen network that resin-based sealers are possibly bonding to.
activity was observed in both crustacean species studied, being significantly higher in C.
activity and conjunctival elastic fibril degeneration related to oxidative stress, and ocular surface inflammation are responsible for the etiopathogenesis of CCh, but neither is solely responsible for the disease.
Neutrophil collagenase, also called matrix metalloproteinase (MMP)-8, polymorphonuclear (PMN) leukocyte collagenase, or collagenase-2, has been identified and characterized as a major collagenolytic
enzyme that causes active periodontal and peri-implant degeneration (APD) in periodontitis and peri-implantitis [3-7].
(172,173) Its collagenolytic
activity is shown by its action on fibroblasts, the main constituent cells of connective tissue of the periodontal ligament, responsible for collagen production.
Rutherford, "The effects of interleukin 1 on collagenolytic
activity and prostaglandin-e secretion by human periodontal-ligament and gingival fibroblast," Archives of Oral Biology, vol.
Screening of producers of proteinases with fibrinolytic and collagenolytic
activities among Micromycetes.
 An important reason for pressure ulcer development is bacterial colonization as it increases collagenolytic
activity and leads to tissue necrosis in such ulcers.
Studies have found that these enzymes can be activated by the simple adhesive system application on dentin substrate, leaving it exposed to collagenolytic
activity and start a degradation of the dentin-bonded interface (Breschi et al., 2010; De Munck et al., 2010), resulting in loss of adhesion of resin composites to this substrate, which can be measured as a decrease in bond strength.