Thus, linagliptin and sitagliptin appeared to promote wound healing by their property of angiogenesis and collagenation
, with some anti-inflammatory action and the stellate shape of the scar, probably suggest that enhanced healing is due to wound contraction rather than enhanced epithelialization.
Wound healing is a multiphase process characterized by wound contraction, granulation, epithelialization, and collagenation
. Wound healing involves 3 phases, that is, inflammation, proliferation, and remodeling [38, 39].
In particular, plant extracts are considered remarkable and promote wound healing through expression and release of growth factors and cytokines, or by accelerating blood clotting, collagenation
, and epithelialization [14, 15].
As healing phases, namely, inflammation, macrophagia, collagenation
, contraction, and epithelization are closely interlinked; it is possible that A.
Thus, we proposed that PR might effectively exert resistance to collagenation by mediating this signaling pathway.
Counteractivity or inhibition of collagenation may help antagonize against liver fibrosis development (An et al.
Granulation tissue in the papain-urea treated group had more macrophages, with less collagenation and fibroblasts (Figure 5).
This was confirmed histopathologically where there was abundant collagenation in the fusidate-treated group.
Conversely, pronounced morphological alterations occurred in alcohol-treated rats, including fat deposition, collagenation
, hepatocellular degeneration, inflammatory responses and necrosis, which were accompanied by a reduction in cell number (Fig.
In dead space wound model also the weight of the granulation tissue of the lupeol treated animal was increased indicating increase of collagenation and absence of monocytes.
Wound healing is a highly ordered and well coordinated process that involves inflammation, cell proliferation, matrix deposition, tissue remodeling, collagenation and epithelialization.
Wound healing involves various phases, i.e., granulation, collagenation
, collagen maturation and scar maturation (Cherry et al.