collagenases


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Related to collagenases: Interstitial collagenase

collagenases

Enzymes that can break down COLLAGEN and gelatin.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Studies on neutrophil collagenase and MMP-18 in clear cell renal cell carcinoma did not demonstrate any increase in their activity in primary tumour tissue or metastases as compared to normal tissue [3,32].
The proposed noninflammatory mechanisms include defective collagenase activity due to decreased uptake of folic acid, blockage of aldosterone synthesis in adrenal cortex, and consequent feedback increase in adrenocorticotropic hormone level and upregulation of keratinocyte growth factor.
Sobi added that the use of Xiapex (collagenase clostridium histolyticum) in men with Peyronie's disease, with a palpable plaque and curvature deformity of at least 30 degrees at the start of therapy, is supported by positive safety and efficacy outcome data from the companies' two double-blind placebo-controlled studies IMPRESS I and II (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies).
In the experimental protocol used in the currentstudy (a "split-mouth" design), MMP-8 (neutrophil-type collagenase, collagenase-2) and MMP-13 (collagenase-3) were both detected in the plasma samples from the different groups of rats but neither was detected in the gingiva (see Section 4).
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases: a review article.
To facilitate the mobility of these cells, an enzyme needed to break down collagen, which is the largest component of the extracellular matrix, called collagenase (matrix metalloproteinases/ MMP), such as MMP-1, -8, and -13.
Nature accomplished this purpose superbly which is why no other enzyme but a "collagenase" can break it into its component parts.
The FDA's Arthritis Advisory Committee voted 12-0 that the treatment, collagenase Clostridium histolyticum, should be approved for treating advanced Dupuytren's, based on the available safety and efficacy data.
The Food and Drug Administration's Arthritis Advisory Committee voted 12-0 that the treatment, collagenase clostridium histolyticum, should be approved for treating advanced Dupuytren's, based on the available safety and efficacy data.
Despite the currently available knowledge base, some studies performed on gelatinases and collagenases in serum do not address the concerns raised by reports of pitfalls and misinterpretations linked to preanalytical aspects of blood processing.
(2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.
The remodeling progresses immediately after myocardial damage with an increased level of collagenases (Janicki et al.