matrix metalloproteinase 13

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matrix metalloproteinase 13

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
EGF, FGF-b, FGF-7, IGF-1, IL-1β, IL-6, IL-13, LIF, oncostatin M, PDGF, PDGF-BB, TGF-α, TGF-β1, TGF-β2, TNF-α.
 
Substrates
Collagens I, II and III, IV, IX, X and XIV; gelatin, α1-ACHYM and plasminogen activator inhibitor 2; aggrecan; perlecan; large tenascin-C and fibronectin; osteonectin; MMP-9.
References in periodicals archive ?
Lopez-Otin, "An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies," Clinica Chimica Acta, vol.
Kahari, "Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck," The American Journal of Pathology, vol.
Kronqvist et al., "Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer," Head and Neck, vol.
Grenman et al., "Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas," The American Journal of Pathology, vol.
Zatonski, "Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas," European Archives of Oto-Rhino-Laryngology, vol.
In the experimental protocol used in the currentstudy (a "split-mouth" design), MMP-8 (neutrophil-type collagenase, collagenase-2) and MMP-13 (collagenase-3) were both detected in the plasma samples from the different groups of rats but neither was detected in the gingiva (see Section 4).
Collagenase-3 (matrix metalloproteinase-expression is induced in oral mucosal epithelium during chronic inflammation.
(3), (4), (7), (9), (19), (20) MMP-13, sometimes referred to as collagenase-3, exhibits the broadest specificity of the collagenases, with the highest activity against type II collagen, the primary collagen found in cartilage, and has been expressed in pathologies associated with excessive ECM degradation.
IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.
Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interaction.
Collagenase-3 (MMP13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.