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(3), (4), (7), (9), (19), (20) MMP-13, sometimes referred to as collagenase-3, exhibits the broadest specificity of the collagenases, with the highest activity against type II collagen, the primary collagen found in cartilage, and has been expressed in pathologies associated with excessive ECM degradation.
IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.