matrix metalloproteinase 13

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matrix metalloproteinase 13

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
EGF, FGF-b, FGF-7, IGF-1, IL-1β, IL-6, IL-13, LIF, oncostatin M, PDGF, PDGF-BB, TGF-α, TGF-β1, TGF-β2, TNF-α.

Substrates
Collagens I, II and III, IV, IX, X and XIV; gelatin, α1-ACHYM and plasminogen activator inhibitor 2; aggrecan; perlecan; large tenascin-C and fibronectin; osteonectin; MMP-9.

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References in periodicals archive ?

Lopez-Otin, "An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies," Clinica Chimica Acta, vol.

Kahari, "Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck," The American Journal of Pathology, vol.

Kronqvist et al., "Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer," Head and Neck, vol.

Grenman et al., "Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas," The American Journal of Pathology, vol.

Zatonski, "Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas," European Archives of Oto-Rhino-Laryngology, vol.

Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma

In the experimental protocol used in the currentstudy (a "split-mouth" design), MMP-8 (neutrophil-type collagenase, collagenase-2) and MMP-13 (collagenase-3) were both detected in the plasma samples from the different groups of rats but neither was detected in the gingiva (see Section 4).

A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations

Collagenase-3 (matrix metalloproteinase-expression is induced in oral mucosal epithelium during chronic inflammation.

Efficacy of metronidazole in combination with amoxicillin and doxycycline in adult periodontitis

(3), (4), (7), (9), (19), (20) MMP-13, sometimes referred to as collagenase-3, exhibits the broadest specificity of the collagenases, with the highest activity against type II collagen, the primary collagen found in cartilage, and has been expressed in pathologies associated with excessive ECM degradation.

IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.

Novel formulation of THIAA & berberine offers selective inhibition of matrix metalloproteinase expression within the extracellular matrix

Biochemical characterization of human collagenase-3. J Biol Chem.

Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis

Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interaction.

Collagenase-3 (MMP13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.

Colorectal carcinoma susceptibility and metastases are associated with matrix metalloproteinase-7 promoter polymorphisms