There seems to be a follicle-specificity in enzymatic treatment and digestion protocol and in this study, collagenase IV was superior to collagenase I for retrieving large number of oocytes without losing morphological normality.
In conclusion, enzymatic digestion of porcine ovarian cortex with collagenase is a useful tool for retrieving porcine preantral follicles of different stages.
Two large, multicenter, double-blind, randomized, placebo-controlled, phase 3 clinical studies demonstrated that the use of collagenase is appropriate in Peyronie's disease when the following criteria were met: stable disease, curvature between 30[degrees] and 90[degrees], no hourglass deformity, no calcified plaque, plaque is not proximally located at the base of the penis, and normal erectile function (Gelbard et al., 2013; Levine et al, 2015).
The Panel notes that intralesional collagenase is a therapy for curvature; it does not treat pain or ED.
The measured mass (normalized to maximum mass following immersion in solution) of the M/R and M/R + MeSNA films following incubation in saline or saline + collagenase is
presented in Figure 2.
Collagenase is a drug that breaks down collagen in damaged tissue and helps healthy tissue to grow.
The most potent collagenase is the "crude" collagenase secreted by the anaerobic bacteria "Clostridium histolyticum".
The enzyme collagenase is derived from the fermentation by "Clostridium histolyticum".
Pharmacology: Used in the treatment of skin ulcers and sever burns, collagenase is able to digest collagen in necrotic tissue at physiological pH.
a chemical debriding agent not intended for long- term use on granulating wounds.
M(r) 92,000 type IV collagenase is
increased in plasma of patients with colon cancer and breast cancer.