collagenase


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collagenase

 [kŏ-laj´ĕ-nās]
an enzyme that catalyzes the degradation of collagen.

col·la·gen·ase

(kol-ăj'ĕ-nās),
A proteolytic enzyme that acts on one or more of the collagens.

collagenase

(kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.

matrix metalloproteinase 1

A 43-kD tissue enzyme (EC 3.4.24.7), encoded by MMP1 on chromosome 11q21-q22, which cleaves collagens, cytokines and extracellular matrix.

Cytokine inducers 
BTC, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF, HRG-β1, IFN-β, IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, sIL-6 Rα, IL-8, IL-10, MIF, oncostatin M, PD-ECGF, PDGF, PDGF-AA, PDGF-BB, PF4, TGF-α, TGF-β1, TNF-α, TNF-β, VEGF.
 
Substrates
3 α-chains of native Collagens I, II, III, VII, VIII and IX; gelatin, aggrecan, hyaluronidase-treated versican, proteoglycan link protein, large tenascin-C, α1-antitrypsin/α1-proteinase inhibitor (α1-AT), α1-antichymotrypsin, pregnancy zone protein, ovostatin, entactin/nidogen, MBP, GST-TNF/TNF peptide, l-selectin, serum amyloid A, IGF-BP3, IGF-BP5, IL-1β, MMP-2, MMP-9.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on one or more of the collagens.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on collagens.
References in periodicals archive ?
Collagenase clostridium histolyticum is a proteinase that hydrolyzes collagen, resulting in destruction of collagen deposits.
The destroyed regional collagen fiber with collagenase at the "Quchi" acupoint had no effect on the levels of serum IL-1[beta] and TNF-[alpha], and there was no significant difference compared with Group M (P > 0.05).
Overall, increasing enzyme exposure time was found to be more detrimental than collagenase concentration for subsequent viability, proliferation, and matrix forming capacity (sGAG and collagen) of these cells resulting in nonuniform cartilaginous matrix deposition.
cilicica (ACRM) displayed the highest hyaluronidase, collagenase and elastase inhibitory activity with the inhibition value of 49.49%, 39.90% and 53.78%, respectively.
* The report reviews Collagenase 3 (Matrix Metalloproteinase-13 or MMP13 or EC 3.4.24.) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
The collagenase type XI of 1.5 mg was added to 1 mL preheated DMEM-HG containing 5% FBS (37[degrees]C) to prepare 1.5 mg/mL collagenase type XI from clostridium histolyticum solution containing 5% FBS, the solution was filtered through 0.22 pm filter, and stored at -20[degrees]C.
(13) There is a strong correlation between the production of inactive collagenase and responding fibroblasts.
This enzyme, called collagenase, dissolves collagen and is harvested from a bacterium, clostridium histolyticum.
In-vitro collagenase enzymatic degradation was performed as per the method described by Connolly et al.
A separate experiment was conducted to investigate resistance to collagenase digestion.
Of these, overexpression of MMP13 which is a collagenase appeared to be contributing to tumor cell invasion, metastasis, and poor prognosis [10].
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases: a review article.