ITGA2

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ITGA2

A gene on chromosome 5q11.2 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. Alpha-2 beta-1 heterodimers serve as receptors for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin, and is responsible for adhesion of platelets and other cells to the extracellular matrix, modulation of collagen and collagenase gene expression and organisation of newly synthesised extracellular matrix.
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Platelets express integrins, such as [[alpha].sub.2][[beta].sub.1] (collagen receptor), [[alpha].sub.IIb][[beta].sub.3] (fibrinogen receptor), and [[alpha].sub.V][[beta].sub.1] (fibronectin receptor).
Glycoprotein VI (GPVI) Collagen Receptor. Honokiol (extracted from magnolia), a specific antagonist of collagen receptor glycoprotein VI, which is expressed on human platelets [109], was shown to attenuate A[beta]-induced memory impairment, which was attributed to its antioxidant activity [110].
van Golen, "Type I collagen receptor ([alpha]2[beta]1) signaling promotes prostate cancer invasion through RhoC GTPase," Neoplasia, vol.
It was reported for dermal fibroblasts that the collagen synthesis is negatively regulated by interaction with collagen fibers via a certain collagen receptor, and mesenchymal stem cells also express collagen receptors [37, 38].
Other glycoprotein disorders include collagen receptor disorders, ADP receptor disorders and Platelet-Type VWD (also called Pseudo-VWD), in which an unusual gain-of-function abnormality of GP lb leads to increased binding of platelet GP IbN/IX to von Willebrand factor.
On the one hand, activated platelets show enhanced surface expression of collagen receptor pGPVI in ACS as determined by flow cytometry, in accordance with previous findings (4, 5).
Collagenase is the drug which binds on the collagen receptor.
This was accompanied by reduced tyrosine phosphorylation of the tyrosine kinase Syk and phospholipase Cgamma2, components of the platelet glycoprotein VI collagen receptor signaling pathway.
In contrast, in patients with von Willebrand disease (VWD) type I and borderline to normal ristocetin-cofactor (von Willebrand factor [VWF]:RCo) activity, collagen receptor density correlates inversely with closure time in a high-shear-stress system, that is, the Platelet Function Analyzer (PFA-100, Dade-Behring, Deerfield, Ill).
The [[alpha].sub.2][[beta].sub.1] (GP Ia/IIa) integrin is a collagen receptor. A deficiency has been reported in a patient who lacked an aggregation response to collagen, whose platelets did not adhere to collagen, and who had a lifelong mild bleeding disorder.
Several collagen receptors have been identified on the platelet surface.
Recent advances in thrombosis and hemostasis: platelet collagen receptors. 2008.