COL1A2

(redirected from collagen, type I, alpha 2)

COL1A2

A gene on chromosome 7q21.3 that encodes the pro-alpha2 chain of type-I collagen, the triple-helix (two-alpha1, one-alpha2 chain) form of collagen found in most connective tissue and abundant in bone, cornea, dermis and tendon.

Molecular pathology
COL1A2 mutations occur in osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, autosomal recessive Ehlers-Danlos syndrome (classic type), idiopathic osteoporosis and atypical Marfan syndrome.
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References in periodicals archive ?
Gene name Gene Fold YB-1 Scramble-RPKM change KD-RPKM Collagen, type III, Col3a1 4.58 1.89125 0.412824 alpha 1 Collagen, type V, alpha 2 Col5a2 3.40 4.68447 1.37872 Thrombospondin 2 Thbs2 2.15 0.414252 0.193934 Reelin Reln 1.89 0.916106 0.48511 Thrombospondin 1 Thbs1 1.79 93.503 52.3547 Collagen, type I, alpha 2 Col1a2 1.78 5.134 2.87674 Collagen, type IV, alpha 2 Col4a2 1.69 119.857 70.8253 Collagen, type IV, alpha 1 Col4a1 1.63 202.428 123.942 Integrin beta 6 Itgb6 1.61 6.48106 4.03229 FIGURE 1: The YB-1 cistrome in hepatic progenitor cells.