Rapallini et al., "Location of colistin
resistance gene mcr-1 in Enterobacteriaceae from livestock and meat," Journal of Antimicrobial Chemotherapy, vol.
Our results have revealed that 100% of CPE isolates were susceptible to colistin
. Similar susceptibility results have been reported from Haryana India and Spain with 100% and 97.5% CPE isolates being susceptible respectively10,11.
in South Africa (SA) is only authorised in exceptional circumstances following application to and approval from the Medicines Control Council, as stipulated in section 21 of the Medicines and Related Substances Control Act.
Overall, there was a statistically significant increase in trends of antimicrobial consumption for carbapenems, tigecycline and colistin
, while a decline in consumption was noted for aminoglycosides (p<0.05).
In our study, carbapenem resistance was found with a rate of 100% and aminoglycoside resistance was found with a rate of 90% in Acinetobacter spp., whereas colistin
resistance was not found.
cloacae) were sensitive to tigecycline but resistant to polymyxin-B and colistin
, showing probable genetic diversity of the isolates.
Aerosolized plus intravenous colistin
versus intravenous colistin
alone for the treatment of ventilator-associated pneumonia: a matched case-control study.
Clinical pharmacokinetics and pharmacodynamics of colistin
. Clin Pharmacokinet.
Novodiag CarbaR+ is combining multiplex qPCR and microarray in one single test allowing cost-effective and fast analysis of the most common carbapenemase-producing enterobacteriaceae and colistin
Regarded as one of the last resorts, polymyxin B has been used alternatively in China, especially following the surge of CRKP only susceptible to colistin
. Thus, researchers are paying more attention to polymyxin B options as monotherapy or combination therapy, medication doses, and adverse effects.
It has been shown that ceragenins have different resistance mechanisms than colistin
and can be used in colistin-resistant Klebsiella pneumoniae isolates (Hashemi et al.
Among the isolates of Acinetobacter baumanii all the isolates were 100% sensitive to Colistin
, Tigecycline and 100% resistance was seen to Ampicillin.