Specific substances such as Menthol and Camphor are higher in percentage that is 2.6% and 4.73% respectively,1 they attenuate the excitability of nerve membranes and of the specific itch mediating C-fibers and A-fibers.2 Both substances act by attaching to the transient receptor potential (TRP) receptor, but the main mechanism of action by which topical menthol reduces pruritus is by attaching onto the cold receptor
TRPM8 which then goes and reaches the A-delta fibers and hence giving a cooling sensation.2 While camphor attaches onto the warm receptor TRPV3.3 Furthermore, menthol also helps in providing general anaesthesia by being a positive modulator of GABA type a receptor.
Julius, "Identification of a cold receptor
reveals a general role for TRP channels in thermosensation," Nature, vol.
Further studies should therefore be directed at exploring both hot and cold receptor
expression in the healthy and inflamed tooth pulp, thus helping to further elucidate dental pain mechanisms and direct the development of targeted therapies.
Curiously, the new cold receptor
is found on nerve cells that also sport a receptor for hot temperatures and capsaicin, the chemical that gives chilies and other foods their fiery kick.
"This is the first cold receptor
," says Ardem Patapoutian of the Scripps Research Institute in La Jolla, Calif.
Cold showers have been shown to relieve depression symptoms due to the intense impact of cold receptors
in the skin, which send an overwhelming amount of electrical impulses from the peripheral nerve endings to the brain.
This new technology, the company claims, stimulates the cold receptors
in the mouth cavity rather than the taste receptors on the tongue.
He added that a potential mechanism to explain the increased risk of coronary events associated with decreasing temperature is the stimulation of cold receptors
in the skin and therefore the sympathetic nervous system, leading to a rise in catecholamine levels.
Renata covers the exposed areas of my legs with surgical stockings, and ensures cold receptors
on my wrists and the backs of my knees and ankles are well-protected.
Menthol puts the hot receptors to sleep and the cold receptors
send out a lot more signals in comparison.
In the case of massage, the touch can stimulate pressure, heat, and cold receptors
in the body, sending positive sensations through the nervous system to the brain.
Warmth and cold receptors
are more sensitive to changes in skin temperature than constant temperatures.