Herbal Medicines for Cold Hypersensitivity in the Hands and Feet: A Systematic Review and Meta-Analysis.
Objectives: Cold hypersensitivity in the hands and feet (CHHF) and Raynaud's phenomenon (RP) are prevalent among Asian populations, especially among women, who exhibit a higher rate of cold hypersensitivity that may be associated with gynecological problems.
30 mg/kg; human equivalent dose approximately 10mg/kg ) ameliorated cold hypersensitivity. By contrast, the anticonvulsant pregabalin (p.o.
(The presence of cold hypersensitivity following nine weeks of oxaliplatin treatment was not mentioned.) Also, in rats, no loss of DRG neurons or sensory nerve axonal degeneration was reported 31 days after the last oxaliplatin treatment .
Five weeks of pamidronate treatment resulted in a significant decrease in cold hypersensitivity, as determined using the acetone and cold plate tests (Figures 4(b) and 4(c)), but had no effect on mechanical or heat sensitivity, grip strength, or open field exploration results (Figures 4(a) and 4(d)-4(f)).
In the current study, chronic pamidronate treatment resulted in reversal of BMD loss and cold hypersensitivity but had no effect on mechanical or cutaneous heat hypersensitivity, deep musculoskeletal discomfort, or overall physical activity.
studied the association of cold hypersensitivity in the hands and feet with functional dyspepsia .
Lee, "Cold Hypersensitivity in the Hands and Feet May Be Associated with Functional Dyspepsia: Results of a Multicenter Survey Study," Evidence-Based Complementary and Alternative Medicine, vol.
TRPV1 antagonists make patients temporarily blind to heat, which Zylka speculates is analogous to what happened when his lab deleted the animals' circuit that detects heat: cold hypersensitivity
Among them are hypertension, alkaptonuria, systemic chondromalacia, relapsing polychondritis, and familial cold hypersensitivity
. (4) Other systemic diseases associated with petrified auricles are scleroderma, acromegaly, diabetes mellitus, hypopituitarism, and hypothyroidism.
Patients describe an array of sensory symptoms in the hands and/or feet including numbness, tingling, ongoing pain, and mechanical and cold hypersensitivity
. These symptoms significantly impact the quality of life, for example, pain on walking and inability to remove items from a fridge/freezer [1, 2].
This acute neurotoxic side effect, the only major dose-limiting toxicity associated with oxaliplatin use , is characterized by the rapid onset of spontaneous severe pain and cold hypersensitivity
in the hands, feet, perioral area, or throat [5-7].