cold hemagglutinin disease


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Related to cold hemagglutinin disease: warm agglutinin disease, cold antibody

cold he·mag·glu·ti·nin dis·ease

a condition associated with the presence of hemagglutinating autoantibody active in vivo, but in vitro particularly or solely active in the cold; when the concentration of IgM antibody is high there may be increased serum viscosity, but clinical manifestations (due to hemagglutination) usually appear following exposure to cold; hemolysis usually is mild but may be severe, resulting in autoimmune hemolytic anemia, cold antibody type.