cold hemagglutinin disease

(redirected from cold agglutinin syndrome)

cold he·mag·glu·ti·nin dis·ease

a condition associated with the presence of hemagglutinating autoantibody active in vivo, but in vitro particularly or solely active in the cold; when the concentration of IgM antibody is high there may be increased serum viscosity, but clinical manifestations (due to hemagglutination) usually appear following exposure to cold; hemolysis usually is mild but may be severe, resulting in autoimmune hemolytic anemia, cold antibody type.
References in periodicals archive ?
The category of cold hemolysins includes 2 distinct disease entities: cold agglutinin syndrome and paroxysmal cold hemoglobinuria, either of which should demonstrate a DAT positive only with C3 antisera.
Measurement of the third component of complement bound to red blood cells in patients with the cold agglutinin syndrome. J Clin Invest 1973; 52(2):493-501.
ABBREVIATIONS: AHG = anti-human globulin; AIHA = autoimmune hemolytic anemia; CAS = cold agglutinin syndrome; DAY = direct antiglobulin test; HDN = hemolytic disease of the newborn; IAT = indirect antiglobulin test; IHA = immune hemolytic anemia; LISS = low ionic strength solution; PAM = prophylactic antigen-matched; PCH = paroxysmal cold hemoglobinuria; PEG = polyethylene glycol; RBC = red blood cell; WAIHA = warm autoimmune hemolytic anemia.