cold agglutinin disease


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Related to cold agglutinin disease: cold antibody

cold agglutinin disease

Cold agglutinin syndrome Clinical immunology An immune disorder characterized by IgM autoantibodies that optimally agglutinate RBCs at very low temperatures–eg, 4ºC; low titers–< 1:32 of cold agglutinins–CAs are detectable in many normal subjects; polyclonal CAs ↑ after certain infections–eg, mycoplasma, CMV, EBV, trypanosomiasis, and malaria, peak in 2-3 wks and are insignificant if non-hemolytic; CAs may occur in any Pt with acquired hemolytic anemia and a positive direct Coomb's test; certain antibodies have been implicated–eg, anti-I, -i, -Pr, -Gd, Sda. See Autoantibody. Cf 'Room temps. '.

cold agglutinin disease

Any of a group of disorders marked by hemolytic anemia, obstruction of the microcirculation, or both. It is caused by agglutination of red blood cells by immunoglobulins that precipitate at cool or cold temperatures. The most common symptom is Raynaud's phenomenon. Cold agglutinin disease often occurs transiently after infection with Mycoplasma pneumoniae or Epstein-Barr virus. Often the cause is idiopathic.
References in periodicals archive ?
Cold Agglutinin Disease is a very, rare, immune mediated condition, in which components of blood agglutinate in the vessels, causing thrombus formation with subsequent loss of blood supply.
In addition, Apellis and SFJ have entered into a letter of intent to negotiate and enter into a joint development agreement to support Apellis' clinical development programs for APL-2 for the treatment of patients with cold agglutinin disease and warm antibody hemolytic anemia.
The author mentioned the treatment methods recommended for cold agglutinin disease, which is a type of autoimmune hemolytic anemia (AIHA).
Idiotypic/antiidiotypic interactions are suggested to suppress tissue damage caused by autoantibodies in a number of conditions including autoimmune thyroiditis, SLE, pernicious anemia, cold agglutinin disease, myasthenia gravis, and idiopathic thrombocytopenic purpura.