cofactor

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cofactor

[ko´fak-ter]

an element or principle, e.g., a coenzyme, with which another must unite in order to function.

heparin cofactor II a member of the serpin group that inhibits thrombin.

co·fac·tor

(kō'fak'ter, tōr),

1. Synonym(s): coenzyme

2. An atom or molecule essential for the action of a large molecule, for example, heme in hemoglobin, magnesium in chlorophyll. Solo metal ions are regarded as cofactors for proteins, but not as coenzymes.

Farlex Partner Medical Dictionary © Farlex 2012

cofactor

(kō′făk′tər)

1. One of two or more contributing factors.

2. A substance, such as a metallic ion or coenzyme, that must be associated with an enzyme for the enzyme to function.

co·fac·tor

(kō'fak'tŏr)

1. Synonym(s): coenzyme.

2. An atom or molecule essential for the action of a large molecule; e.g., heme in hemoglobin, magnesium in chlorophyll.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cofactor

a substance that is essential for the catalytic activity of some enzymes, binding to the enzyme only during the reaction. Cofactors can be metallic ions, or nonprotein organic molecules (coenzymes) such as vitamins in the B-COMPLEX.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

co·fac·tor

(kō'fak'tŏr)

An atom or molecule essential for the action of a large molecule.

Medical Dictionary for the Dental Professions © Farlex 2012

References in periodicals archive ?

Cofactor biosynthesis: an organic chemist's treasure trove.

Analysis of the intermediary metabolism of a reductive chemoautotroph

Levine, chief executive officer of ADVENTRX, "The initiation of this Phase II clinical trial for CoFactor represents an important milestone in the global registration strategy for our lead product development program.

ADVENTRX Begins Phase II Clinical Trial of Breast Cancer Treatment

Where [MATHEMATICAL EXPRESSION NOT REPRODUCIBLE IN ASCII.] and [MATHEMATICAL EXPRESSION NOT REPRODUCIBLE IN ASCII.] are [n.sub.i] x 1 vectors of known coefficients of the [k.sub.1th] and [k.sub.2th] common founder and second founder cofactors; [m.sub.1i], and [m.sub.2i] are number of marker cofactors considered from common founder and second founder haplotypes from population i.

A haplotype-based method for QTL mapping of [F.sub.1] populations in outbred plant species

The point of the analysis is that the cofactors of the Jacobian matrix can have their own, sometimes decisive, nonparametric properties.

Topics in Nonparametric Comparative Statics and Stability

Deficiencies in nutrient cofactors will also expose functional weakness of those enzymes predisposed to dysfunction due to genetic defects.

The nutri-genomic impact on histamine metabolism

It could also help chemists design artificial cofactor molecules and enzymes to catalyse reactions which are currently difficult or impossible.

Form follows function in molybdenum enzymes

Four of the 12 steps are the relatively simple addition or removal of water, while the other 8 are mediated by specific cofactors. Cofactors are a special class of molecules that we term chimeromers (see below), which function as construction enablers in synthesizing the components of the metabolome.

The canonical network of autotrophic intermediary metabolism: minimal metabolome of a reductive chemoautotroph

And apparently, the basis for the effect depends on changes in the way the Pparg2 receptor interacts with its cofactors and in its sensitivity to a fat-produced hormone known as adiponectin, which influences blood sugar control and fatty acid breakdown.

High-fat diet fights off beneficial gene variant

From this observation we conclude that apo A5 519W is a crucial cofactor for developing hypertriglyceridemia in patients with apo E2/2.

Hyperlipidemia in patients with apolipoprotein E 2/2 Phenotype: apolipoprotein A5 S19W mutation as a cofactor

where the summation occurs over c marker cofactors. For each cofactor c, a set [k.sub.c] of interconnected haplotypes have been identified.

Mapping quantitative trait loci in plant breeding populations: use of parental haplotype sharing. (Crop Breeding, Genetics & Cytology)

The findings suggest that circumcision is an important cofactor in human papillomavirus (HPV) infection and cervical cancer, reported Dr.

Male circumcision tied to lower cervical Ca risk. (Lower Risk of HPV Infection in Men)

The premise is that since zinc is a cofactor in cellular proliferation, including it in dressings should be beneficial.