coenzyme Q-10
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coenzyme Q-10
(ko-en-zime-cue-ten) ,coQ10
(trade name),ubiquinol
(trade name),ubiquinone
(trade name)Classification
Therapeutic: antioxidantsAction
A co-factor in oxidative respiration for the Krebs cycle and the electron transport chain important for mitochondrial ATP generation. It also has antioxidant activity and membrane stabilizing ability.
Therapeutic effects
Antioxidant effects.
Pharmacokinetics
Absorption: Poor absorption in the GI tract, absorbed primarily in the small intestine.
Distribution: Unknown.
Metabolism and Excretion: Metabolized in all tissues, elimination via biliary and fecal excretion.
Half-life: 34 hrs.
Time/action profile
ONSET | PEAK | DURATION | |
---|---|---|---|
PO | Unknown | 5–10 hrs | Unknown |
Contraindications/Precautions
Contraindicated in: Obstetric: Pregnancy and lactation; Allergy/hypersensitivity.
Use Cautiously in: Hypotension; Surgery (discontinue 2 weeks prior to procedure).
Adverse Reactions/Side Effects
Central nervous system
- dizziness
Cardiovascular
- hypotension
Dermatologic
- rash
Gastrointestinal
- nausea
- vomiting
- diarrhea
- heartburn
- decreased appetite
Interactions
HMG CoA reductase inhibitors (statins) can ↓ coenzyme Q-10 levels.May ↑ risk of clotting with anticoagulants.May have additive hypotensive effects with antihypertensives.May protect againstanthracycline -associated cardiotoxicity.Red yeast can ↓ coenzyme Q-10 levels.May have additive hypotensive effects with herbs that can lower BP including fish oil and L-arginine.Oral (Adults) Coenzyme Q-10 deficiency—150 mg daily; Mitochondrial disorders—150–160 mg daily or 2 mg/kg/day; Heart failure—60–100 mg daily; HIV/AIDS—200 mg daily; Parkinson's disease—300–2400 mg daily; Muscular dystrophy—100 mg daily.
Availability
Soft-gel capsules:
Tablets:
Nursing implications
Nursing assessment
- Monitor BP periodically during therapy.
- Lab Test Considerations: Monitor coagulation studies periodically during therapy.
- Monitor blood glucose during therapy; may cause hypoglycemia.
- Monitor lipid levels and serum lactate periodically during therapy.
Potential Nursing Diagnoses
Activity intoleranceImplementation
- Oral: Administer with a meal containing fat for optimal absorption.
Patient/Family Teaching
- Instruct patient to take with a meal containing fat, as directed.
- May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
Evaluation/Desired Outcomes
- Antioxidant effects in a variety of conditions.
Drug Guide, © 2015 Farlex and Partners
coenzyme Q-10
n.
A form of coenzyme Q containing 10 isoprene units that is the most common form in animals and is used as a dietary supplement for its purported antioxidant properties.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.