coenzyme Q-10

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coenzyme Q-10

(ko-en-zime-cue-ten) ,


(trade name),


(trade name),


(trade name)


Therapeutic: antioxidants
Heart failureCoenzyme Q–10 deficiencyMitochondrial disorders Muscular dystrophyImmune stimulant in HIV infectionParkinson's disease


A co-factor in oxidative respiration for the Krebs cycle and the electron transport chain important for mitochondrial ATP generation. It also has antioxidant activity and membrane stabilizing ability.

Therapeutic effects

Antioxidant effects.


Absorption: Poor absorption in the GI tract, absorbed primarily in the small intestine.
Distribution: Unknown.
Metabolism and Excretion: Metabolized in all tissues, elimination via biliary and fecal excretion.
Half-life: 34 hrs.

Time/action profile

POUnknown5–10 hrsUnknown


Contraindicated in: Obstetric: Pregnancy and lactation; Allergy/hypersensitivity.
Use Cautiously in: Hypotension; Surgery (discontinue 2 weeks prior to procedure).

Adverse Reactions/Side Effects

Central nervous system

  • dizziness


  • hypotension


  • rash


  • nausea
  • vomiting
  • diarrhea
  • heartburn
  • decreased appetite


HMG CoA reductase inhibitors (statins) can ↓ coenzyme Q-10 levels.May ↑ risk of clotting with anticoagulants.May have additive hypotensive effects with antihypertensives.May protect againstanthracycline -associated cardiotoxicity.Red yeast can ↓ coenzyme Q-10 levels.May have additive hypotensive effects with herbs that can lower BP including fish oil and L-arginine.
Oral (Adults) Coenzyme Q-10 deficiency—150 mg daily; Mitochondrial disorders—150–160 mg daily or 2 mg/kg/day; Heart failure—60–100 mg daily; HIV/AIDS—200 mg daily; Parkinson's disease—300–2400 mg daily; Muscular dystrophy—100 mg daily.


Soft-gel capsules:

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor coagulation studies periodically during therapy.
    • Monitor blood glucose during therapy; may cause hypoglycemia.
    • Monitor lipid levels and serum lactate periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance


  • Oral: Administer with a meal containing fat for optimal absorption.

Patient/Family Teaching

  • Instruct patient to take with a meal containing fat, as directed.
  • May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.

Evaluation/Desired Outcomes

  • Antioxidant effects in a variety of conditions.
Drug Guide, © 2015 Farlex and Partners

coenzyme Q-10

A form of coenzyme Q containing 10 isoprene units that is the most common form in animals and is used as a dietary supplement for its purported antioxidant properties.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
Coenzyme Q-10: clinical benefits with biochemical correlates suggesting a scientific breakthrough....
Clinical trial with water-soluble CoQ-10 Effect of hydrosoluble coenzyme Q-10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease (Journal of Hypertension, Mar 1999): In this randomized double-blind placebo-controlled trial among patients receiving antihypertensive medication and with coronary artery disease (n=59: 30 in treatment group, 29 in placebo group), patients received oral coenzyme Q-10 (60 mg twice daily) for 8 weeks.
The National Institutes of Health is finalizing plans to enroll hundreds of early-stage Parkinson's patients in a study of super-high doses of coenzyme Q-10, or CoQ10.
COENZYME Q-10 is a super-antioxidant with a variety of beneficial effects.
There are plenty of other substances with preliminary potential for helping prevent heart disease, but with less research to go on, including L-arginine, coenzyme Q-10 red yeast rice powder and guggulipid.
Therefore it is very common to find product labels only list "active" ingredients such as collagen, lycopene and coenzyme Q-10 without making specific skin, nail, health and appearance claims.
The most commonly used products are fish oil/omega-3/DHA (37.4%), glucosamine (19.9%), echinacea (19.8%), flaxseed oil or pills (15.9%), ginseng (14.1%), combination herb pills (13%), ginkgo biloba (11.3%), chondroitin (11.2%), garlic supplements (11%), and coenzyme Q-10 (8.7%).
"In 2003 we were ahead of the curve when we launched our coenzyme Q-10 in 300 mg," Pigott says.
"Enhanced blood levels of coenzyme Q-10 from an emulsified oral form." In Faruqui SR and Ansari MS (editors).
Specifically, those ingredients and technologies include hyaluronic spheres, coenzyme Q-10 and light refractors.