The cochleate crystalline structure protects the stomach lining and delivers the aspirin more efficiently to the inflamed cells.
The company has tested cochleates as a delivery system for other drugs, as well as micronutrients, but this is the first study which demonstrates the positive effects of the Bioral(TM) system with aspirin.
Pursuant to their understanding, BDSI and Defiante Farmaceutica will negotiate exclusively towards entering into a license agreement (either for an exclusive or non exclusive world wide license, depending upon the terms negotiated between the parties) to develop, manufacture, promote, distribute, sell and sublicense products containing the aspirin cochleates
for all applications.
A "geode" is defined as a nodule of stone having a cavity; thus these new types of cochleates are termed BioGeode(TM) cochleates.
Cochleates are calcium- phospholipid structures composed of naturally occurring materials that "wrap" around the drug or nutrient being introduced into the body.
Mannino was working at incorporating antigens into cochleates
when he and his colleague Susan Gould-Fogerite decided to examine whether cochleates
might also deliver DNA effectively.
com CLTU003 09/30/2003 07:00 r f bc-OH-LanVision-agreemnt (CINCINNATI) Maxim Coding Solutions to Utilize codingANYware Lanvision's Remote Coding Workflow Solution LATU008 09/30/2003 07:00 r f bc-CO-AIRM-New-Director (DENVER) Air Methods Board Appoints New Director NYTU035 09/30/2003 07:00 r f bc-NJ-BioDelivery-prodct (NEWARK) New BioGeode(TM) Cochleates
Could Make Healthy Nutrients More Available In Processed Foods NYTU047 09/30/2003 07:00 r f bc-CT-United-Rentals (GREENWICH) United Rentals Chairman Bradley S.
Others include liposomal formulations, technologies to improve solubility and absorption, delivery via oral, injectable, and pulmonary routes of administration, microspheres, nanoparticles, nasal administration, PEGylated technologies, cochleates
, encapsulated plasmid DNA formulation, intraneuronal biodelivery, folate-mediated drug delivery, among others.