TNX-1300 (double-mutant cocaine esterase) is being developed under an IND and is in Phase 2 development for the treatment of cocaine intoxication.
TNX-1300 (T172R/G173Q double-mutant cocaine esterase 200 mg, i.v.
Bacterial cocaine esterase injected into rats had a half-life of only 15 minutes compared with eight hours for human CocH-albumin.
Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology 2011;36(5):1047-1059.
Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.
Effects of cocaine esterase following its repeated administration with cocaine in mice.
cocaine esterase: a bacterial candidate for novel pharmacokinetic-based therapies for cocaine abuse.
Rapid and robust protection against cocaineinduced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol 2006; 70:1885-91.
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
(56) Bacterial cocaine esterases (CocE), which also metabolise cocaine, have been isolated from Rhodococcus bacteria that grow in the soil around coca plants.
The discovery of Cocaine esterase
, CocE, has been hailed as possible method of helping addicts get off cocaine, reports The Telegraph.
Expanded pipeline with a Phase 2 biologic, TNX-1300 (T172R/G173Q double-mutant cocaine esterase
200 mg, i.v.