cobblestone appearance


Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to cobblestone appearance: ulcerative colitis, Crohn's disease
A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
Gynaecology
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma

cobblestone appearance

Cobblestone pattern A widely used term for multiple, equally-sized rounded densities that project from a single linear surface, when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to roads paved by multiple similarly-sized 'cobbled' stones GI disease A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn's disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules–due to the submucosal edema, while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal 'cobblestoning' may also occur in ulcerative colitis–where ulcers alternate with regenerating mucosa, ischemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue, or amyloid Oral disease Multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden's premalignant multiple hamartoma syndrome
References in periodicals archive ?
Kaplan says that affected dogs "will have thickened keratin layers, loss of cobblestone appearance, and a dry nose." This is a recessive disorder requiring both parents to pass on the gene for a pup to be affected, and signs typically show up before the dog reaches a year of age.
compared the colonoscopic findings between 115 intestinal BD patients and 135 CD patients, and found that ulcer shape, ulcer distribution, ulcer number, absence of aphthous lesions, and a cobblestone appearance were independent discriminating predictors.
[1-4] Its features usually include facial tricholemmomas, acral and palmoplantar keratoses, multiple oral papules, and mucosal fibrosis with a cobblestone appearance. Cowden's disease is also associated with multiple hamartomas of the gastrointestinal tract and cancers of the breast, thyroid, uterus, ovary, lung, skin, and gastrointestinal tract.
Three months posttransplant, the cobblestone appearance of the patient's face had disappeared, and he was able to close his eyes and eat normally.
In this presentation, it was noted on physical exam that Jordan's eyelids did not have the classic cobblestone appearance. Allergic conjunctivitis, therefore, was ruled out.