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A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
"As we've explained in our correspondence, the repairs to the cobbles were temporary and permanent repairs will follow imminently."
Residents say they want the cobbles put back as they are the heart of town and part of the reason why thousands visit every year.
And if he chaperones Britain's defending champion Chris Froome safely from Arras to Roubaix, it will be the best result on cobbles since serial killer Pat Phelan got his comeuppance in Weatherfield.
COBBLE WOBBLES Street faves Andrea and Kevin help an unsteady Nadia
Froome did not even see a cobble as his Tour defence ended 12 months ago after three crashes in two days, but this time he was guided expertly by the brilliant Geraint Thomas.
For each of the tools a combination of morphometric, petrological and wear analysis data is recorded to look for evidence of a possible source for the cobbles and for any indication of selection based on shape, weight and cobble type, for evidence of primary and secondary tool use, artefact modification and usewear history (including any recycling or discard of the tool).
A Corrie fan has got in touch with a conservation group who are inspecting the cobbles to see if they qualify to be preserved as a place of historic interest.
Now Welsh timber experts are hoping to reinvent 19th century technology to find modern uses for "wooden cobbles".
One potential indicator species of natural habitat in New York State is the cobblestone tiger beetle (Cicindela marginipennis Dejean), a rare species adapted to natural river disturbances that maintain its required habitat, cobble bars.
Residents, local schoolchildren and youth groups have been asked to a series of "cobble workshops" to make their mark on the history of Walker.
The cobbles are gone and heavier use means traffic lights are necessary.