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A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma
References in periodicals archive ?
Cobble Hill Towers is a nine-building complex with 188 units facing Warren, Baltic and Hicks Streets.
Another major consideration is that of removing the material from the bore path, whether that is whole cobble-stones, or smaller pieces of these cobble stones, created through mechanically breaking-up the cobble stones with the bit or reamer.
San Diego has also experimented with a cobble rock replacement project, but the only other experience in the field has been in Europe, officials said.
Jerry Walker, Consulting Geologist, July 18, 2011 2 Reserve Estimates for the Cobble Cuesta Structure, Alfred H.
Cobble runs a private practice in Sandy, Utah, where he has lived for more than 20 years and focuses on dyslipidemia, diabetes, cardiovascular diseases (CV), hypertension and primary care medicine.
5m strip of Asphalt road will separate the 2 areas of cobbles which will be used as parking.
The Townhouses of Cobble Hill--de-signed by the architectural firm Adjmi & Andreoli--are being offered in three-, four- and five-bedroom configurations.
As a point of comparison for this May's one deal, in May 2008, there were five closings in Cobble Hill (two of which, because of the disputed boundaries, some people might argue are actually in Boerum Hill).
This fine sediment, according to PWA, would have two impacts: it would decrease the number of cobbles (mid-sized stones) that reach the ocean; and it would alter the fine grained sediment to cobble ratio in the Trestles surfing area.
all upped sticks and headed up to Manchester to transmit the show live from the cobbles.
5km route from Seraing in Belgium across the cobbles of northern France and held off a charging peloton.
JMH Development and Madison Estates are the team behind the successful, and sold out, Cobble Hill project, The Townhouses of Cobble Hill.