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A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The Cobble Beach Golf Resort Community is located ten minutes north of Owen Sound, ON in the township of Georgian Bluffs.
Artefacts including antler picks and hammers, twisted hazel (withy) ropes and handles for hafted stone tools, basket fragments, mine timber (stemples and cut fire wood), several well preserved wooden launders made of oak and alder used for drainage, and perhaps also for ore washing (split and hollowed out logs up to 5m long with the marks of metal tools), and upwards of a thousand cobble stone tools have been recovered from these workings.
Box was staying at the El Reno house with Cobble, who is the son of Tom Cobble, Box's former high school football coach in Enid, Oklahoma.
President of the Cobble Hill Association Roy Sloane is afraid that the scheme "sets a dangerous precedent" but he is satisfied with the revision of plans.
In a separate announcement, Ian Laven who is General Manager of AMTRI Cobble has now been appointed a director of the company.
For at least the last decade, feminist historians, Cobble among them, have been contesting and revising the "June Cleaver" popular image of these post-war years, challenging the notion that Betty Friedan's Feminine Mystique spoke about, or to, working-class and African American women.
"Although we get great feedback from our clinical sites about how well our students do, they will now be even better prepared before they go to their clinicals," Cobble said.
Charisma" five years ago, Cobble points out, and Nader became a pop star on college campuses during the 2000 campaign.
On Sunday, September 15, 2019, a panel of 48 judges take to the 18th fairway at Cobble Beach Golf Resort Community and begin scoring each of these vehicles against others in their class, in order to choose the best in that class.
Madison Realty Capital (MRC) announced the closing of a $297 million construction loan for River Park, a three-building mixed-use development in Cobble Hill by Fortis Property Group.