MTR

(redirected from cobalamin-dependent methionine synthase)

MTR

A gene on chromosome 1q43 that encodes an enzyme which transfers a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. It then remethylates the cofactor using methyltetrahydrofolate.

Molecular pathology
Defects in MTRR cause methylcobalamin deficiency type E and folate-sensitive neural tube defects.
References in periodicals archive ?
Matthews, "Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase," Proceedings of the National Academy of Sciences of the United States of America, vol.
Matthews, "Assignment of enzymatic function to specific protein regions of cobalamin-dependent methionine synthase from Escherichia coli," Biochemistry, vol.
Hcy is an intermediate in sulfur amino acid metabolism, and it is remethylated to Met by the folate- and cobalamin-dependent methionine synthase reaction or metabolized to Cys along the trans-sulfuration pathway (38).