Prevalence of the coagulation factor XIII
polymorphism Val34Leu in women with recurrent miscarriage.
Objective: To provide a comprehensive literature review on roles of coagulation factor XIII
(FXIII) in coagulation, wound healing, neoplasm, bone metabolism, and pregnancy.
Coagulation factor XIII
(FXIII) is activated by thrombin into activated FXIII (FXIIIa).
Enzyme-linked immunosorbent assay for the determination of blood coagulation factor XIII
Asubunit in plasma and in cell lysates.
Influence of blood coagulation factor XIII
and FXIII Val34Leu on plasma clot formation measured by thrombelastograpy.
Congenital blood coagulation factor XIII
deficiency and successful deliveries: a review of the literature.
Tetranucleotide repeat polymorphism at the human coagulation factor XIII
A subunit gene (F13A1), Nucleic Acids Research (1991) 19:4036.
Adany, "Consecutive appearance of coagulation factor XIII
subunit A in macrophages, megakaryocytes, and liver cells during early human development," Blood, vol.
Genotype/phenotype correlations for coagulation factor XIII
: specific normal polymorphisms are associated with high or low factor XIII specific activity.
We developed a pyrosequencing-based genotyping protocol for parallel analysis of the [beta]-fibrinogen (-455G/A and -854 G/A), prothrombin (G20210A), coagulation factor V Leiden (G1691; Arg506G1n), coagulation factor VII (-401G/T and -402 G/A), coagulation factor XIII
(G163T; Val34Leu), plasminogen activator inhibitor-1 (PAI-1; -675 4G/5G), methylenetetrahydrofolate reductase (MTHFR; C677T; Ala222Val), glycoprotein IIIa (GPIIIa; C1565T; Leu33Pro; also known as PlA1/ PlA2), and endothelial nitric oxide synthase (eNOS; G894T; G1u298Asp) polymorphisms, together with the cytochrome P450 2C9 [CYP2C9*1 (wild type)], CYP2C9*2 (C430T; Cys144Arg), CYP2C9*3 (A1075C; Ile359Leu), and CYP2C9*4 (T1076C; Ile359Thr) isoforms, which modulate the effect of warfarin in antithrombotic therapy.