Determination of canine coagulation factor VII
. The Veterinary Journal 190, 305-306.
Weisko RB .Intraoperative use of recombinant activated coagulation factor VII
. Anesthesiology 2002; 96: 1287-89.
Recently, recombinant coagulation factor VII
administration, an approach to improve the prognosis of acute ICH by limiting early hematoma growth via the factor's acute hemostatic effect, showed potential benefits in an early-phase clinical trial but failed to show a significant effect in a phase III clinical trial [15, 16].
In the initiation phase, which is the first phase, coagulation starts when the vasculature is injured and subendothelial cells expose tissue factor (TF), which is the key initiator of haemostasis, that binds to coagulation factor VII
, leading to its activation to FVIIa.
Exposure of the blood to tissue factor triggers the extrinsic coagulation pathway whose function is monitored by the PT through interaction of tissue factor with activated coagulation factor VII
The complex of tTF and blood coagulation factor VII
(F VII) cannot effectively activate coagulation factor X to trigger the blood coagulation because its incomplete structure is unable to bind with cell membrane [8, 9].
The increased INR values with Neoplastin R during unstable anticoagulation, such as in the initial phase of oral anticoagulation treatment, could be explained by fluctuations in coagulation factor VII
(FVII) concentrations owing to the low half-life of FVII.
Use of activated recombinant coagulation factor VII
in patients undergoing reconstruction surgery for traumatic fracture of pelvis or pelvis and acetabulum: a double-blind, randomized, placebo-control.
After each repast, researchers measured concentrations of coagulation factor VII
(FVII), a protein that triggers production of a clotting agent in the blood.
In this model, all clotting is initiated by the combination of tissue factor and activated coagulation factor VII
Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII
and fibrinolysis in healthy young men.