Drug Interactions: Coadministration
of CRESEMBA with strong CYP3A4 inhibitors such as ketoconazole or high-dose ritonavir and strong CYP3A4 inducers such as rifampin, carbamazepine, St.
Jukka-Pekka Visapaa and his colleagues studied the effect of coadministration
of metronidazole and ethanol in young, healthy male volunteers.
The main safety issues raised by the FDA were the risks of hypotension and syncope--effects associated with the drug alone and exacerbated by alcohol and by coadministration
with CYP3A4 inhibitors.
The effectiveness and safety of the coadministration
of memantine HCl extended release and acetylcholinesterase inhibitors (AChEIs), together with donepezil HCl, was based on the results of a randomized and double-blind, placebo-controlled study of 677 outpatients on a stable dose of AChEIs.
of lorcaserin and phentermine for weight management is investigational.
a) Avoid coadministration
of P-glycoprotein inducers.
It 's necessary to use metronidazole in addition to doxycycline and a cephalosporin to cover all the bacteria species associated with pelvic inflammatory disease, according one study "The coadministration
of a cephalosporin with doxycycline for women with PID provides coverage for all anaerobic pathogens except Prevotella species.
3(A) and (B) depict the serum profiles of VPA after oral administration of VPA alone, coadministration
of HQT at 0.
Second, if the reported adverse effect of calcium supplementation on the cardiovascular system is real, it might be due to calcium-induced magnesium depletion, and therefore might be preventable by coadministration
The acute inflammatory cell infiltration and increased expression of COX-2 and iNOS in synovial tissue and articular cartilage following intra-articular injection of MSU crystals in a rat model was inhibited by coadministration
of the energy drink with alcohol counteracted some of the alcohol-induced impairment of response activation, but not response inhibition.
There is evidence that coadministration
of methylmercury and Se may lead to an important synergistic effect (Heinz and Hoffman 1998).